What if cancer cells passed stress down like a family secret? Scientists reveal how DNA damage changes generations of tumor cells — and why that matters. #CancerResearch #CellTracking #TherapyResistance
https://geekoo.news/cancer-cells-under-pressure-what-inheritance-reveals-about-therapy-resistance/
"These data identify developmental lineage as a key determinant of sensitivity to anti-GD2 based immunotherapies and credential #EZH2 inhibitors for clinical testing in combination with anti-GD2 antibody to enhance outcomes for children with #neuroblastoma".
An article that I had missed, by Mabe et al., linking #mesenchymal #tumour cell state, #GD2 expression, #ST8SIA1 expression, and #immunotherapy #TherapyResistance.
https://www.nature.com/articles/s43018-022-00405-x
Sadly, not open access.
Mabe et al. find that GD2 levels correlate with lineage plasticity in neuroblastoma and identify ST8SIA1 as the key enzyme in GD2 synthesis. EZH2 inhibition in mesenchymal neuroblastoma cells elevates ST8SIA1, synergizing with anti-GD2 antibodies.
#ICYMI the recording of the #CancerMoonshot Seminar with Dr. Keith Syson Chan sharing how #celldeath induces non-classical mechanisms of #therapyresistance can be viewed at https://youtu.be/Nim2JWD9YkQ.
Geekoo
Arjan Boltjes
Claire McCarthy