🦷 A new study by @[email protected] High-throughput paleoproteomics method using MALDI-CASI-FTICR mass spectrometry to estimate biological sex from tooth enamel. Great success on 130 individuals from medieval Great Moravia. #Bioarchaeology #Archaeology #Proteomics #TooMS 😉 #Teammasspec

biorxiv.org/content/10.648...
🧵 Thread: 1️⃣/ Caroline Tokarski delivering a masterclass on how #massspec revolutionises our understanding of cultural materials! Her slide perfectly encapsulates the multifaceted insights we can extract - from artist intention to societal context. #teammasspec #heritage
Alba Alvarez Martin from @rijksmuseum.bsky.social presenting "Making Mass Spectrometry Accessible in Cultural Institutions". The historical irony isn't lost as Rembrandt's anatomy lesson is juxtaposed with #teammasspec in an amphitheatre designed for anatomical dissection.
Alternative perspectives at the "Advanced Mass Spectrometry in Cultural Heritage" symposium in Bordeaux! www.u-bordeaux.fr/evenements/s... The 3rd of these essential gathering brings together experts from across the globe to explore cutting-edge applications in heritage science. #teammasspec
🧵 Thread: 1️⃣ Fascinating paper by Stewart et al. shows robust method for sex determination using peptides in tooth enamel. Great potential for #archaeology with fragmentary remains where DNA is degraded. #palaeoproteomics #ZooMS #teammasspec figshare.com/s/a861c0d74d...
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6️⃣ This approach builds on solid foundations from food science - while offering new applications in archaeology. It has legs. NB: @helenfewlass.bsky.social, you will soon have your NIR model for bone collagen estimation out... right? 👍 #teammasspec #archaeology #bioarchaeology
2/9 The authors present two novel algorithms: isoBLAST and ClassiCOL, which embrace peptide ambiguity rather than trying to eliminate it - a conceptual shift in palaeoproteomics. #teammasspec
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3/5 🔥 Most exciting breakthrough: MALDI-FTICR successfully analyzed BURNT BONES! These are typically excluded from ZooMS due to collagen breakdown. They achieved taxonomic IDs on carbonized specimens where MALDI-TOF completely failed. #archaeology #teammasspec
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2️⃣ Key innovation: untargeted approach using ion mobility separation (TIMS) with rapid Evosep LC enables global peptide analysis in minutes rather than conventional 60-min Orbitrap runs. Works for both human and cattle remains. #teammasspec
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2️⃣ Team including @fridowelker.bsky.social analyzed predicted enamel proteins from 232 primate species, simulating ancient fragmentation patterns to test phylogenetic signal preservation. Important validation study! #teammasspec
Frido Welker (@fridowelker.bsky.social)

🇳🇱 Interested in ancient proteins & Human Evolution 🇩🇰 | See @Welkergroup.bsky.social for a lot more fun! | 🇪🇺 #ERC_PROSPER | Globe Institute, University of Copenhagen | 🦷🦴💀

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