Longer Internal Exons Tend to Have More Tandem Repeats and Experience Insertions and Deletions More Frequently

#Indels #IntrinsicallyDisorderedRegions #IDRs #TandemRepeats #Preprint

https://www.biorxiv.org/content/10.1101/2024.11.03.621752v1

This is an interesting study from a pathophysiology perspective, but moreover for the possibility of future targeting treatment to specific signaling proteins. #schizophrenia #dna #TandemRepeats

Rare Genetic Phenomenon Linked to Schizophrenia
https://scitechdaily.com/rare-genetic-phenomenon-linked-to-schizophrenia/

Rare Genetic Phenomenon Linked to Schizophrenia

Researchers have discovered a strong correlation between the development of schizophrenia and a rare form of a genetic variant known as tandem repeats. In our cells, DNA acts as a language, creating the unique characteristics that make each of us who we are. Tandem repeats occur within DNA when a

SciTechDaily
More on Borgs from @BanfieldLab!
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RT @PLOSBiology
Extrachromosomal #Borg elements in methane-consuming #archaea are scattered with rapidly evolving nucleotide #TandemRepeats; those within genes encode amino acid repeats that create intrinsically disordered regions @MScholmerich @BanfieldLab #PLOSBiology https://plos.io/3Y0cw3R
https://twitter.com/PLOSBiology/status/1619024436161646595
Tandem repeats in giant archaeal Borg elements undergo rapid evolution and create new intrinsically disordered regions in proteins

This study shows that extrachromosomal elements associated with methane-consuming Methanoperedens archaea (known as Borgs) are scattered with nucleotide tandem repeats that evolve rapidly. When occurring within genes, the resulting amino acid repeats create largely intrinsically disordered regions.

Extrachromosomal #Borg elements in methane-consuming #archaea are scattered with rapidly evolving nucleotide #TandemRepeats; those within genes encode amino acid repeats that create intrinsically disordered regions @MScholmerich @BanfieldLab #PLOSBiology https://plos.io/3Y0cw3R
Tandem repeats in giant archaeal Borg elements undergo rapid evolution and create new intrinsically disordered regions in proteins

This study shows that extrachromosomal elements associated with methane-consuming Methanoperedens archaea (known as Borgs) are scattered with nucleotide tandem repeats that evolve rapidly. When occurring within genes, the resulting amino acid repeats create largely intrinsically disordered regions.

Extrachromosomal #Borg elements in methane-consuming #archaea are scattered with rapidly evolving nucleotide #TandemRepeats; those within genes encode amino acid repeats that create intrinsically disordered regions @MScholmerich @BanfieldLab #PLOSBiology https://plos.io/3Y0cw3R
Tandem repeats in giant archaeal Borg elements undergo rapid evolution and create new intrinsically disordered regions in proteins

This study shows that extrachromosomal elements associated with methane-consuming Methanoperedens archaea (known as Borgs) are scattered with nucleotide tandem repeats that evolve rapidly. When occurring within genes, the resulting amino acid repeats create largely intrinsically disordered regions.

Extrachromosomal #Borg elements in methane-consuming #archaea are scattered with rapidly evolving nucleotide #TandemRepeats; those within genes encode amino acid repeats that create intrinsically disordered regions @MScholmerich @BanfieldLab #PLOSBiology https://plos.io/3Y0cw3R
Tandem repeats in giant archaeal Borg elements undergo rapid evolution and create new intrinsically disordered regions in proteins

This study shows that extrachromosomal elements associated with methane-consuming Methanoperedens archaea (known as Borgs) are scattered with nucleotide tandem repeats that evolve rapidly. When occurring within genes, the resulting amino acid repeats create largely intrinsically disordered regions.