Here’s the simplified protocol of using #Paxlovid in patients on a CNI (#cyclosporine or #tacrolimus) in #transplant
Can you use #Paxlovid in #kidney #transplant recipients? Or will ritonavir cause CNI toxicity?
Of course you can use it! Just be sensible about both: stopping, and starting the CNI (#Tacrolimus mostly)
See our experience published here https://pubmed.ncbi.nlm.nih.gov/37099447
Withholding tacrolimus starting the day before initiation of nirmatrelvir/ritonavir with resumption 3 days after completion of therapy resulted in a low incidence of supratherapeutic levels but a short period of subtherapeutic levels for many patients. AKI was infrequent. The data are limited by the …
@DerApotheker
Für Patient:innen mit #Immunsuppression wie #Tacrolimus muss auch beachtet werden, dass sich der Immun-Spiegel nach absetzen vom PPI ändern kann!