StructBiolCommunicationsMar 10, 2025
The crystal structure of the murine TRIM21 PRYSPRY domain in complex with suramin was solved at 1.3 Å resolution. This video shows the conformational changes upon suramin binding. #TRIM21 #E3Ligases #CrystalStructure https://doi.org/10.1107/S2053230X25000913
LOPAC library screening identifies suramin as a TRIM21 binder with a unique binding mode revealed by crystal structure

This communication describes the crystal structure of TRIM21 in complex with suramin, providing new opportunities to target this E3 ligase.

Acta Crystallographica Section F
Seth Thomas ScanlonMar 31, 2023

Out now in @sciencemagazine: Aamir Mukadam, William McEwan & colleagues treat mouse models of #tau pathology with anti-tau #antibodies by engaging cytosolic antibody receptor #TRIM21!

https://bit.ly/Sci_abn1366

with an accompanying Perspective by Rebecca Nisbet

https://bit.ly/Sci_adg9800

#neurodegeneration #immunotherapy