Hacker NewsAromatic 5-silicon rings synthesized at last
#HackerNews #Aromatic #5-silicon #rings #synthesized #at #last #aromaticchemistry #siliconrings #materialsinnovation #syntheticchemistry #sciencebreakthrough
ScienceOpen๐๐ 'Repositioning antivirals against COVID-19: Synthetic pathways, mechanisms, and therapeutic insights.' - a #DrugRepurposing Research article on #ScienceOpen:
โก๏ธ https://www.scienceopen.com/document?vid=86a9a26d-fa33-4c20-8ef2-41c90ddc56fa
#REPO4EU #COVID19Research #Antivirals #MedicinalChemistry #SyntheticChemistry
Repositioning antivirals against COVID-19: Synthetic pathways, mechanisms, and therapeutic insights.
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" class="first" dir="auto" id="d6481623e211">The pandemic of COVID-19 has ignited a global race to locate effective therapies with drug repositioning emerging as a leading strategy due to its cost-effectiveness and established safety profiles. Remdesivir, Favipiravir, Hydroxychloroquine, and Chloroquine have been the focus of rigorous clinical trials to determine their therapeutic potential against SARS-CoV-2. This article delves into the innovative synthetic strategies behind these drugs, providing a blueprint for researchers navigating the complex landscape of antiviral development. Beyond synthesis, we explore the fascinating mechanisms of action: hydroxychloroquine and chloroquine elevate lysosomal pH to impede autophagy and viral replication; favipiravir, a nucleoside analogue, induces lethal mutagenesis or RNA chain termination and remdesivir disrupts viral RNA synthesis through delayed chain termination. By merging synthetic methodologies with mechanistic insights, this article offers a comprehensive resource aimed at accelerating the development of potent COVID-19 therapies and underscores the crucial part that chemistry in addressing global health emergencies. It also underscores the vital function of chemistry in addressing global health emergencies and highlights how innovative drug design and repurposing can provide rapid responses to emerging infectious diseases. This fusion of chemistry and virology not only advances our understanding of drug action but also paves the way for the discovery of new therapeutic agents crucial in future pandemics. </p>
Beilstein-InstitutStarting tomorrow ๐ July 24, 2025 at ๐ 4 pm CESTโฌ: Online #BeilsteinTalk "New electrophiles, strategies, and catalysts for cross-electrophile coupling" with Daniel Weix from the University of Wisconsin-Madison.
Participation is FREE โ just register ๐ https://www.beilstein-institut.de/en/talks/organic-chemistry-new-electrophiles-strategies-and-catalysts-for-cross-electrophile-coupling/?M=y
#catalyst #SyntheticChemistry #SyntheticOrganicChemistry #BeilsteinTalks
Join the #BeilsteinTalk "New electrophiles, strategies, and catalysts for cross-electrophile coupling" with Daniel Weix from the University of Wisconsin-Madison on ๐ July 24, 2025 ๐ 4โ5 pm CEST.
Participation is FREE โ just register ๐ https://www.beilstein-institut.de/en/talks/organic-chemistry-new-electrophiles-strategies-and-catalysts-for-cross-electrophile-coupling/?M=y
#catalyst #SyntheticChemistry #SyntheticOrganicChemistry #BeilsteinTalks
Save the date ๐ July 24, 2025 ๐ 4โ5 pm CEST
Online #BeilsteinTalk "New electrophiles, strategies, and catalysts for cross-electrophile coupling" with Daniel Weix from the University of Wisconsin-Madison.
Register for FREE! ๐ https://www.beilstein-institut.de/en/talks/organic-chemistry-new-electrophiles-strategies-and-catalysts-for-cross-electrophile-coupling/?M=y
#catalyst #SyntheticChemistry #SyntheticOrganicChemistry #BeilsteinTalks
Ele Willoughby, PhDHappy birthday to chemist William Henry Perkin (1838-1907)! This #lino print โWilliam Henry Perkin Discovers Mauveโ is about how the British chemist & entrepreneur made the serendipitous discovery of the 1st synthetic organic dye: mauveine. โ
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Perkins entered the Royal College of Chemistry in London in 1853 when he was only 15, studying with August Wilhelm von Hofmann. ๐งต1/n
#linocut #printmaking #sciart #chemistry #syntheticChemistry #dye #histstm #chemist #FashionHistory #histchem #MastoArt
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Perkins entered the Royal College of Chemistry in London in 1853 when he was only 15, studying with August Wilhelm von Hofmann. ๐งต1/n
#linocut #printmaking #sciart #chemistry #syntheticChemistry #dye #histstm #chemist #FashionHistory #histchem #MastoArt
Happy birthday to chemist William Henry Perkin (1838-1907)! This #lino block print โWilliam Henry Perkin Discovers Mauveโ is about how the British chemist & entrepreneur made the serendipitous discovery of the 1st synthetic organic dye: mauveine. โ
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Perkins entered the Royal College of Chemistry in London in 1853 when he was only 15,
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#linocut #printmaking #sciart #chemistry #serendipity #syntheticChemistry #dye #histstm #chemist #FashionHistory #histchem #purple #mauve #colour
Boing BoingScientist who synthesized the active ingredient in the powerful psychedelic salvia also broke ground on open access publishing https://boingboing.net/2018/01/08/salvinorin-a.html #abc:arXivbioRxivChemRxiv #syntheticchemistry #psychedelics #scholarship #openaccess #publishing #addiction #chemistry #salvia #drugs #Post