I know it isn't the fashion any more but when pollen counts were high and one's sinuses and ears throw a fit nothing on earth worked as well as #Sudafed. Lord how I miss that stuff.

I think I’m on like day 3 of this gnarly cold I have. Didn’t respond to allergy meds. It’s not covid or influenza A or B. Runny nose but with congestion, cough, sore throat, violent sneezing fits, itchy nose & ears, congested ears. Took some #sudafed yesterday. Just took Tylenol cold & flu.

Hoping something will help. The worst part is not being able to breathe. My shift to start watching the #grandkids is to start tmrw. If I don’t feel better by evening, I’ll let their mom know. She won’t be happy but I’ll likely be watching them anyway. I just don’t want them to get sick.

It's #Winter and yet I'm having some sort of #Allergy fit today. My ears feel like I've just gotten off of a plane and my sinuses are stuffy and my nose is a smidge runny but I'm not sick. Oh how I miss #Sudafed.

It took five decades from the 1970s for the FDA to finally admit last year that oral phenylephrine, used as a decongestant in Sudafed and Lemsip, doesn't actually do anything.

https://www.scientificamerican.com/article/how-two-pharmacists-figured-out-that-decongestants-dont-work/

#ColdAndFlu #Phenylephrine #FDA #Decongestants #Lemsip #Sudafed #ClinicalPharmacology

How Two Pharmacists Figured Out That Decongestants Don’t Work

A loophole in FDA processes means older drugs such as those in oral decongestants weren’t properly tested. Here’s how we learned the most popular one doesn’t work

Scientific American

"#Phenylephrine doesn’t work better than a #placebo. So why is it still on shelves?"

I knew it!

https://youtu.be/ZlFF7A8nk0w?si=ybxqqSKAjevNcHW0

#Pharmacy #OverTheCounter #Sudafed

Why useless decongestants are still for sale

YouTube
The spectacular downfall of a common, useless cold #medicine
This week's unanimous vote on #phenylephrine's ineffectiveness was decades in the making. Advisers for the #FDA this week voted unanimously, 16 to 0, that oral doses of phenylephrine—found in brand-name products like #Sudafed PE, #Benadryl #Allergy Plus Congestion, #Mucinex Sinus-Max, and Nyquil Severe Cold & Flu—are not effective at treating a stuffy nose.
https://arstechnica.com/health/2023/09/the-spectacular-downfall-of-a-common-useless-cold-medicine/
The spectacular downfall of a common, useless cold medicine

This week's unanimous vote on phenylephrine's ineffectiveness was decades in the making.

Ars Technica
The spectacular downfall of a common, useless cold medicine https://arstechnica.com/health/2023/09/the-spectacular-downfall-of-a-common-useless-cold-medicine/ This week's unanimous vote on phenylephrine's ineffectiveness was decades in the making 💊 #Sudafed #Medicine #Medication
The spectacular downfall of a common, useless cold medicine

This week's unanimous vote on phenylephrine's ineffectiveness was decades in the making.

Ars Technica

Decongestant ingredient in popular products does not work, #FDA concludes

Advisory panel reviewed studies of #phenylephrine, an active ingredient in #Benadryl, #Mucinex, #Sudafed PE and #Tylenol
https://www.theguardian.com/us-news/2023/sep/12/decongestant-ingredient-does-not-work-fda-phenylephrine
#Health

Decongestant ingredient in popular products does not work, FDA concludes

Advisory panel spent two days reviewing studies of phenylephrine, an active ingredient in Benadryl, Mucinex, Sudafed PE and Tylenol

The Guardian

nobody:

me considering buying #decongestants:

I don't want to make #meth, I just want to breathe!

THE METH MAN DOESN'T MAKE YOU SIGN A BOOK!

#sudafed

My #antidepressant (#desvenlafaxine aka #Pristiq) is a #phenethylamine. That's rare. It shares that skeleton with other big names like #MDMA, #mescaline, and #Sudafed.

It's a #SSNRI, blocks #serotonin reuptake 5-10x more strongly than #norepinephrine, and may increase #dopamine turnover in the prefrontal cortex.

It has some subjective aspects quite reminiscent of #phenethylamines I've tried.

#drugs #pharma #pharmacology #antidepressants