#Tumor-produced
#interleukin-1α & LIF promote extramedullary
#hematopoiesis. LIF directly expands
#SplenicNicheCells while IL-1α induces TNFα production in hematopoietic stem & progenitor cells to activate splenic niche cells
#PLOSBiology https://plos.io/41jMOJb 
Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis
This study shows that tumor-produced IL-1α and LIF promote extramedullary hematopoiesis. LIF directly expands splenic niche cells while IL-1α induces TNFα production in hematopoietic stem and progenitor cells to activate splenic niche cells; both expand myeloid-biased splenic hematopoiesis.
#Tumor-produced
#interleukin-1α & LIF promote extramedullary
#hematopoiesis. LIF directly expands
#SplenicNicheCells while IL-1α induces TNFα production in hematopoietic stem & progenitor cells to activate splenic niche cells
#PLOSBiology https://plos.io/41jMOJb Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis
This study shows that tumor-produced IL-1α and LIF promote extramedullary hematopoiesis. LIF directly expands splenic niche cells while IL-1α induces TNFα production in hematopoietic stem and progenitor cells to activate splenic niche cells; both expand myeloid-biased splenic hematopoiesis.
#Tumor-produced
#interleukin-1α & LIF promote extramedullary
#hematopoiesis. LIF directly expands
#SplenicNicheCells while IL-1α induces TNFα production in hematopoietic stem & progenitor cells to activate splenic niche cells
#PLOSBiology https://plos.io/41jMOJb Tumor-derived interleukin-1α and leukemia inhibitory factor promote extramedullary hematopoiesis
This study shows that tumor-produced IL-1α and LIF promote extramedullary hematopoiesis. LIF directly expands splenic niche cells while IL-1α induces TNFα production in hematopoietic stem and progenitor cells to activate splenic niche cells; both expand myeloid-biased splenic hematopoiesis.
PLOS Biology
