Layer-specific changes in sensory cortex across the lifespan in mice and humans - Nature Neuroscience

The principal layer architecture of the sensory cortex is altered with aging. The authors show that overall thinning of the primary somatosensory cortex is driven by deep layer degeneration but that layer IV is more pronounced in old age.

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Dr Nick Holmes 💚🦆🌶💉🇺🇦 on Twitter

“hello #brainstim folk. If you aim to stimulate #somatosensory cortex, please ignore the '2cm rule' for finding #S1-hand. This heuristic appears in the majority of #TMS papers. We know this heuristic is wrong (papers below), for example (red=M1-hand, blue=S1-hand) 1/6:”

Dorsal root ganglia control nociceptive input to the central nervous system

Information transmitted along the peripheral somatosensory nerves can be actively modified at the dorsal root ganglion (DRG). This study demonstrates the existence of tonic and dynamic GABAergic filtering of action potentials traveling through the DRG, with therapeutic implications for pain relief.

Dorsal root ganglia control nociceptive input to the central nervous system

Information transmitted along the peripheral somatosensory nerves can be actively modified at the dorsal root ganglion (DRG). This study demonstrates the existence of tonic and dynamic GABAergic filtering of action potentials traveling through the DRG, with therapeutic implications for pain relief.

Dorsal root ganglia control nociceptive input to the central nervous system

Information transmitted along the peripheral somatosensory nerves can be actively modified at the dorsal root ganglion (DRG). This study demonstrates the existence of tonic and dynamic GABAergic filtering of action potentials traveling through the DRG, with therapeutic implications for pain relief.