Mastodawn

Heather Winterstein's death after repeated Ontario hospital ER visits was accidental, inquest jury finds
The inquest jury examining the death of Heather Winterstein has found the Indigenous woman's death in a St. Catharines, Ont., hospital was from septic shock and accidental, and has issued 68 recommendations. The 24-year-old collapsed in the emergency department in 2021 after trying to...
https://www.cbc.ca/news/canada/hamilton/heather-winterstein-coroner-s-inquest-findings-9.7173876?cmp=rss

CBC Canada Apr 22

Death of woman who collapsed in Ontario hospital after repeated ER visits was accidental, inquest jury finds
The inquest jury examining the death of Heather Winterstein has found the Indigenous woman's death in a St. Catharines, Ont., hospital was from septic shock and accidental, and has issued 68 recommendations. The 24-year-old collapsed in the emergency department in 2021 after tryin...
https://www.cbc.ca/news/canada/hamilton/heather-winterstein-coroner-s-inquest-findings-9.7173876?cmp=rss

CBC Top Stories Apr 22

CBC Health Apr 22

Heather Winterstein's death after repeated Ontario hospital ER visits was accidental, inquest jury finds
The inquest jury examining the death of Heather Winterstein has found the Indigenous woman's death in a St. Catharines, Ont., hospital was from septic shock and accidental, and has issued 68 recommendations. The family of the 24-year-old, who collapsed in the emergency department afte...
https://www.cbc.ca/news/canada/hamilton/heather-winterstein-coroner-s-inquest-findings-9.7173876?cmp=rss

Vietnamnet BOT Dec 4

Một cụ bà 78 tuổi, nặng 100kg, đã được cứu sống ngoạn mục từ tình trạng 'chín phần tử vong'. Bệnh nhân bị sốc nhiễm trùng dẫn đến ngưng tim, ngưng thở nhưng đã qua cơn nguy kịch nhờ nỗ lực hồi sức tích cực của đội ngũ y bác sĩ đa chuyên khoa.

#y_tế #sức_khỏe #cứu_sống #bệnh_nhân #sốc_nhiễm_trùng #ngưng_tim
#healthcare #health #medical #patient #septicshock #cardiacarrest #Vietnam

https://vietnamnet.vn/cuu-nguoi-phu-nu-nang-100kg-chin-phan-tu-vong-2469464.html

Cứu người phụ nữ nặng 100kg 'chín phần tử vong'

Bệnh nhân 78 tuổi nặng 100kg sốc nhiễm trùng và ngưng tim - ngưng thở sau khi sốt. Bà đã được cứu sống nhờ hồi sức tích cực đa chuyên khoa.

Vietnamnet.vn

mymedschool Nov 10, 2025

Bacterial endotoxins from Gram-negative bacteria cause fever, inflammation, and septic shock via lipid A activation. #BacterialEndotoxin #LPS #GramNegative #Sepsis #SepticShock #LipidA #Microbiology #Immunology #Pathophysiology #USMLE #MedicalEducation

https://mymedschool.org/portfolio/u01-03-018-bacterial-endotoxin/?utm_source=mastodon&utm_medium=jetpack_social

Bacterial Endotoxin — Structure, Mechanism, and Clinical Impact

Explore bacterial endotoxins — lipopolysaccharide (LPS) molecules of Gram-negative bacteria responsible for septic shock and systemic inflammation through lipid A–mediated immune activation.

mymedschool.org

mymedschool Nov 9, 2025

Learn key differences between bacterial exotoxins and endotoxins and their clinical effects. #Exotoxins #Endotoxins #BacterialToxins #Microbiology #Pathogenesis #GramNegative #GramPositive #LPS #ToxinMechanism #USMLE #MedicalEducation #ClinicalMicrobiology #SepticShock #BacterialVirulence

https://mymedschool.org/portfolio/u01-03-016-features-of-exotoxins-and-endotoxins/?utm_source=mastodon&utm_medium=jetpack_social

Bacterial Exotoxins Explained: Botulinum, Tetanus, Cholera, Diphtheria, and Shiga Toxins | USMLE Microbiology

Learn how major bacterial exotoxins cause disease — from Clostridium botulinum to Shigella dysenteriae. Understand their targets, mechanisms, and clinical effects for high-yield USMLE microbiology preparation.

mymedschool.org

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Romain Barthélémy Sep 15, 2023

@razvan @BakkeHK Not at all. The purpose of using #albumin in #SepticShock is precisely to prevent or mitigate #glycocalyx damage. If oncontic pressure gradient was the purpose, any synthetic colloid would do the job (actually, they won’t, because of the altered endothelial layer, as you suggested)

https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00697-1

https://link.springer.com/article/10.1007/s00134-022-06740-y

Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review - Annals of Intensive Care

The endothelial glycocalyx comprises a complex layer of membrane-bound proteoglycans, secreted glycosaminoglycans, glycoproteins, glycolipids and bound plasma proteins such as albumin and antithrombin associated with the endothelial surface. The glycocalyx plays an important role in vascular homeostasis, regulating vascular permeability and cell adhesion, and acts as a mechanosensor for hemodynamic shear stresses; it also has antithrombotic and anti-inflammatory functions. Plasma proteins such as albumin are physiologically bound within the glycocalyx, thus contributing to stability of the layer. Albumin is the major determinant of plasma colloid osmotic pressure. In addition, albumin transports sphingosine-1-phosphate which has protective endothelial effects, acts as a free radical scavenger, and has immunomodulatory and anti-inflammatory effects. This review examines the physiological function of the endothelial glycocalyx and the role of human albumin in preserving glycocalyx integrity and the microcirculation.

SpringerOpen

Romain Barthélémy Sep 11, 2023

#Albumin Should Be Remembered When Patients With #SepticShock Are Resuscitated

“Although no significant difference in 28-day mortality rate or 90-day mortality rate was observed between the use of albumin and #crystalloids, #colloids appeared to be more effective than crystalloids in stabilizing hemodynamic end points”

I couldn't agree more. Sometimes you have to find what to do at the moment. It is safe and may help.

https://journal.chestnet.org/article/S0012-3692(23)00654-2/fulltext

#FOAMcc #CHEST #CriticalCare #Sepsis #Hemodynamics