SenMayo
A 125-gene set (15 studies) for #Senescence/#SASP in Bone/Bone marrow/Adipose/Brain...
#Senolytic readout
vs GenAge & CellAge
MIF as a key SASP gene!
Dr. Dominik Saul, Joshua Farr & Sundeep Khosla labs Nature Comms 2022
https://www.nature.com/articles/s41467-022-32552-1
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues - Nature Communications
Identification of senescent cells in vivo remains a challenging task. Here the authors present and validate a senescence gene set called SenMayo enriched in human and murine aged tissues.
Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression
#senescence #Senolytic
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.058794
Elated to be selected as a recipient of @
[email protected] Liver Disease Scholar 2022
#LiverDisease #Senolytic#Senescence #ImmuneSurveillance
Next-gen #Senolytic
#ImmuneCheckpointBlockade activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells->
⏬adverse phenotypes in🐭#Aging+#NASH
Dr. Yoshikazu Johmura & Makoto Nakanishi labs Nature 2022
https://www.nature.com/articles/s41586-022-05388-4
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes - Nature
PD-L1 expression by senescent cells renders them resistant to clearance by CD8 T cells, suggesting PD-L1 as a target for mitigating the effects of ageing.
Hao Yin
Aging Highlights
Rio Sugimura