SPINA TeamFeb 8, 2025

Growing evidence supports a role of sensorimotor and autonomic #neuropathy in #syndrome_T or #SORSHOT, i.e. reduced quality of life in treated #hypothyroidism. #SPINA_GT and #SPINA_GD predict nerve function and depression.

https://pubmed.ncbi.nlm.nih.gov/38811750/

https://doi.org/10.1038/s41598-024-63158-w

Impaired autonomic function and somatosensory disturbance in patients with treated autoimmune thyroiditis - PubMed

Despite treatment with levothyroxine, hypothyroidism and autoimmune thyroiditis (AIT) may be associated with reduced quality of life (QoL), an enigmatic condition referred to as "syndrome T". Peripheral neuropathy, described in untreated thyroid disease, could be a contributing mechanism. We analyse …

PubMed
SPINA TeamFeb 2, 2025

Again, a study showed a strong influence of endocrine disruptors on #thyroid homeostasis. Exposure to butylparaben significantly reduces #SPINA-GD, whereas ethylparaben slightly increases #SPINA_GT in pregnancy.

https://pubmed.ncbi.nlm.nih.gov/39889471/

https://doi.org/10.1016/j.ecoenv.2025.117818

Associations between urinary parabens and thyroid hormone homeostasis across trimesters in Taiwanese pregnant women - PubMed

Few studies have explored the link between paraben exposure and thyroid hormone homeostasis in pregnant women across trimesters. The present study involved 97 pregnant women from southern Taiwan (2013-2014), and involved measuring urinary methyl, ethyl, propyl, and butyl parabens, as well as serum t …

PubMed
Show threadJohannes W. DietrichMay 29, 2024
Should we, therefore, classify #syndrome_T as a psychosomatic disease? This would be premature and probably wrong. We found signs of sensorimotor and autonomic #neuropathy that depend on autoimmunity and #thyroid's secretory capacity (#SPINA_GT).
SPINA TeamMar 24, 2024

#SPINA_GT, #SPINA_GD and Jostel's TSH index (#JTI or #TSHI) are predictors of survival in patients with #Takotsubo syndrome (#stress #cardiomyopathy), as recently demonstrated in the international GEIST registry.

https://pubmed.ncbi.nlm.nih.gov/38502972/
https://doi.org/10.1016/j.ebiom.2024.105063

Takotsubo syndrome outcomes predicted by thyroid hormone signature: insights from cluster analysis of a multicentre registry - PubMed

This research was not funded by any public, commercial, or not-for-profit agencies.

PubMed
SPINA TeamDec 2, 2023
#SPINA_Thyr may be useful for monitoring of #endocrine disruptors. #SPINA_GD correlates to paraben excretion, and #SPINA_GT is modified due to exposure to butylparaben. https://doi.org/10.1007/s11356-023-31277-y https://pubmed.ncbi.nlm.nih.gov/38038926/
Johannes W. DietrichOct 28, 2023
#Thyroid's secretory (#SPINA_GT) is higher in borderline personality disorder (#BPD) compared to controls. Is this a result of dynamical compensation or from sympathetic innervation of the thyroid gland? https://doi.org/10.3390/jcm12216702
Stress-Mediated Abnormalities in Regional Myocardial Wall Motion in Young Women with a History of Psychological Trauma

Background: Psychosocial stress has been associated with the development and progression of atherosclerotic cardiovascular disease (CVD). Previously, we reported subtle differences in global longitudinal strain in somatically healthy women with a psychiatric diagnosis of borderline personality disorder (BPD). This study aimed to investigate the impact of BPD on segmental myocardial wall motion using speckle tracking echocardiography (STE) analysis. Methods: A total of 100 women aged between 18 and 38 years were included in this study. Fifty patients meeting the diagnostic criteria for BPD were recruited from the Department of Psychiatry (LWL-University Hospital Bochum) and compared with fifty age-matched healthy control subjects without previous cardiac disease. Laboratory tests and STE were performed with segmental wall motion analysis. Results: The BPD group had a higher prevalence of risk factors for CVD, with smoking and obesity being predominant, when compared with the control group. Other cardiovascular parameters such as blood pressure, glucose, and cholesterol levels were also elevated, even though not to pathological values. Moreover, in the STE analysis, the BPD group consistently exhibited decreased deformation in nine myocardial wall regions compared with the control group, along with a shift toward higher values in the distribution of peak pathological segments. Additionally, significantly higher values of free thyroxine concentration and thyroid’s secretory capacity were observed in the BPD group, despite falling within the (high-) normal range. Conclusions: BPD is associated with chronic stress, classical risk factors, and myocardial wall motion abnormalities. Further exploration is warranted to investigate the relationship between high-normal thyroid metabolism, these risk factors, and myocardial function in BPD patients. Long-term follow-up studies would be valuable in confirming the potential for predicting adverse events.

MDPI
SPINA TeamOct 14, 2023
#Nickel is a toxic metal and an important endocrine disruptor. Recent research shows that exposure to nickel impairs #thyroid's secretory capacity (#SPINA_GT). https://pubmed.ncbi.nlm.nih.gov/37800147/ https://doi.org/10.3389/fendo.2023.1145153
Nickel as a potential disruptor of thyroid function: benchmark modelling of human data - PubMed

The highest median value for blood Ni concentration was observed for the male population and amounted 8,278 µg/L. Accordingly, the statistically significant correlation was observed only in the male population, for Ni-fT4 and Ni-SPINA-GT pairs. The existence of a dose-response relationship was estab …

PubMed
SPINA TeamJul 16, 2023
Both #SPINA_GT and #SPINA_GD are reduced in myalgic encephalomyelitis / chronic fatigue syndrome (#MECFS). SPINA-GD is especially low in persons with antibodies to selenoprotein P, suggesting a pivotal role of selenium in ME/CFS. https://pubmed.ncbi.nlm.nih.gov/37423160/ https://doi.org/10.1016/j.redox.2023.102796
Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone - PubMed

Chronic Fatigue Syndrome (CFS) presents with symptoms of hypothyroidism, including mental and physical fatigue, poor sleep, depression, and anxiety. However, thyroid hormone (TH) profiles of elevated thyrotropin and low thyroxine (T4) are not consistently observed. Recently, autoantibodies to the Se …

PubMed
SPINA TeamJun 22, 2023
In a prospective study including women with #euthyroid autoimmune #thyroiditis treatment with #vitamin_D increased #SPINA_GT, and therapy with selenomethionine raised #SPINA_GD, in parallel to improved #sexual function and reduced #depressive symptoms. https://doi.org/10.3390/nu15122815
Sexual Function and Depressive Symptoms in Young Women with Euthyroid Hashimoto’s Thyroiditis Receiving Vitamin D, Selenomethionine and Myo-Inositol: A Pilot Study

Thyroid autoimmunity is associated with an increased risk of sexual dysfunction. The aim of this study was to compare sexual functioning and depressive symptoms in women with Hashimoto’s thyroiditis receiving different treatments. The study included euthyroid women with autoimmune thyroiditis, untreated or receiving vitamin D, selenomethionine, or myo-inositol. Apart from measuring antibody titers and hormone levels, all participants completed questionnaires evaluating female sexual function (FSFI) and depressive symptoms (BDI-II). In untreated women, the overall FSFI scores and domain scores for desire, arousal, lubrication, and sexual satisfaction were lower than in women receiving vitamin D, selenomethionine, and myo-inositol. In the vitamin D-treated women, the total FSFI scores and scores for desire and arousal were higher than in women receiving the remaining micronutrients. The BDI-II score was lowest in the vitamin D-treated women and highest in the untreated patients with thyroiditis. Vitamin D-treated women were also characterized by lower antibody titers and higher testosterone levels than the women receiving the remaining micronutrients. There were no differences in sexual functioning and depressive symptoms between the selenomethionine- and myo-inositol-treated women. The study results suggest that although all antibody-lowering treatments are associated with better sexual functioning and well-being in young women with euthyroid autoimmune thyroiditis, the greatest benefits are observed in patients receiving vitamin D.

MDPI
SPINA TeamFeb 2, 2023
Both #SPINA_GT and #SPINA_GD correlate with multiple #biomarker​s for #cardiovascular_risk.
https://pubmed.ncbi.nlm.nih.gov/36680358/ https://doi.org/10.1177/10815589221149187
Thyroid-stimulating hormone within the normal reference range has a U-shaped association with the severity of coronary artery disease in nondiabetic patients but is diluted in diabetic patients - PubMed

Too high or too low thyroid-stimulating hormone (TSH) has been associated with the progress and prognosis of coronary artery disease (CAD). However, whether TSH within its normal reference range plays a role in the severity of CAD remains unclear. In this observational study, we explored the potenti …

PubMed