Growing evidence supports a role of sensorimotor and autonomic #neuropathy in #syndrome_T or #SORSHOT, i.e. reduced quality of life in treated #hypothyroidism. #SPINA_GT and #SPINA_GD predict nerve function and depression.
https://pubmed.ncbi.nlm.nih.gov/38811750/
https://doi.org/10.1038/s41598-024-63158-w
Impaired autonomic function and somatosensory disturbance in patients with treated autoimmune thyroiditis - PubMed
Despite treatment with levothyroxine, hypothyroidism and autoimmune thyroiditis (AIT) may be associated with reduced quality of life (QoL), an enigmatic condition referred to as "syndrome T". Peripheral neuropathy, described in untreated thyroid disease, could be a contributing mechanism. We analyse …
Endocrine disruptors have a strong effect on the peripheral #thyroid hormone metabolism. A recent study showed a nonlinear dose-response relationship between #PFAS and step-up deiodinase activity (#SPINA_GD).
https://pubmed.ncbi.nlm.nih.gov/39556482/
https://doi.org/10.1210/clinem/dgae798
Association between per- and polyfluoroalkyl substance exposures and thyroid homeostasis parameters - PubMed
This study revealed that PFAS exposures may affect peripheral thyroid hormone sensitivity instead of central among U.S. general adults, enhancing our understanding of the correlation between PFAS exposure and thyroid hormones and providing insights into potential health implications.
#SPINA_GT, #SPINA_GD and Jostel's TSH index (#JTI or #TSHI) are predictors of survival in patients with #Takotsubo syndrome (#stress #cardiomyopathy), as recently demonstrated in the international GEIST registry.
https://pubmed.ncbi.nlm.nih.gov/38502972/
https://doi.org/10.1016/j.ebiom.2024.105063
Takotsubo syndrome outcomes predicted by thyroid hormone signature: insights from cluster analysis of a multicentre registry - PubMed
This research was not funded by any public, commercial, or not-for-profit agencies.
#SPINA_Thyr may be useful for monitoring of
#endocrine disruptors.
#SPINA_GD correlates to paraben excretion, and
#SPINA_GT is modified due to exposure to butylparaben.
https://doi.org/10.1007/s11356-023-31277-y https://pubmed.ncbi.nlm.nih.gov/38038926/ Total step-up
#deiodinase activity (
#SPINA_GD) is upregulated in metabolic syndrome, as demonstrated by a strong correlation to the triglyceride-glucose index.
https://pubmed.ncbi.nlm.nih.gov/37946276/ https://doi.org/10.1186/s40001-023-01501-zExploring the association between triglyceride-glucose index and thyroid function - PubMed
The present study established a noteworthy association between TyG and thyroid parameters, indicating a strong link between IR and thyroid dysfunction. Further investigations are warranted to validate these results.
Yet another study shows that
#SPINA_GD goes down under substitution therapy with levothyroxine, underscoring the role of the TSH-T3 feedforward control.
https://pubmed.ncbi.nlm.nih.gov/36401211/
Serum TSH, 25(OH) D and phosphorus levels predict weight loss in individuals with diabetes/prediabetes and morbid obesity: a single-center retrospective cohort analysis - PubMed
Serum TSH, phosphorus, and 25(OH) D levels predict WL% in euthyroid patients with diabetes/prediabetes and morbid obesity. TSH predictivity seems to be a function of thyroid autoimmunity present with increased frequency in this cohort. Greater levels of phosphorus within the reference range and a su …
Both
#SPINA_GT and
#SPINA_GD are reduced in myalgic encephalomyelitis / chronic fatigue syndrome (
#MECFS). SPINA-GD is especially low in persons with antibodies to selenoprotein P, suggesting a pivotal role of selenium in ME/CFS.
https://pubmed.ncbi.nlm.nih.gov/37423160/ https://doi.org/10.1016/j.redox.2023.102796Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone - PubMed
Chronic Fatigue Syndrome (CFS) presents with symptoms of hypothyroidism, including mental and physical fatigue, poor sleep, depression, and anxiety. However, thyroid hormone (TH) profiles of elevated thyrotropin and low thyroxine (T4) are not consistently observed. Recently, autoantibodies to the Se …
In a prospective study including women with
#euthyroid autoimmune
#thyroiditis treatment with
#vitamin_D increased
#SPINA_GT, and therapy with selenomethionine raised
#SPINA_GD, in parallel to improved
#sexual function and reduced
#depressive symptoms.
https://doi.org/10.3390/nu15122815
Sexual Function and Depressive Symptoms in Young Women with Euthyroid Hashimoto’s Thyroiditis Receiving Vitamin D, Selenomethionine and Myo-Inositol: A Pilot Study
Thyroid autoimmunity is associated with an increased risk of sexual dysfunction. The aim of this study was to compare sexual functioning and depressive symptoms in women with Hashimoto’s thyroiditis receiving different treatments. The study included euthyroid women with autoimmune thyroiditis, untreated or receiving vitamin D, selenomethionine, or myo-inositol. Apart from measuring antibody titers and hormone levels, all participants completed questionnaires evaluating female sexual function (FSFI) and depressive symptoms (BDI-II). In untreated women, the overall FSFI scores and domain scores for desire, arousal, lubrication, and sexual satisfaction were lower than in women receiving vitamin D, selenomethionine, and myo-inositol. In the vitamin D-treated women, the total FSFI scores and scores for desire and arousal were higher than in women receiving the remaining micronutrients. The BDI-II score was lowest in the vitamin D-treated women and highest in the untreated patients with thyroiditis. Vitamin D-treated women were also characterized by lower antibody titers and higher testosterone levels than the women receiving the remaining micronutrients. There were no differences in sexual functioning and depressive symptoms between the selenomethionine- and myo-inositol-treated women. The study results suggest that although all antibody-lowering treatments are associated with better sexual functioning and well-being in young women with euthyroid autoimmune thyroiditis, the greatest benefits are observed in patients receiving vitamin D.
Impaired sensitivity to thyroid hormone correlates to osteoporosis and fractures in euthyroid individuals - PubMed
In elderly euthyroid individuals, impaired sensitivity to thyroid hormones correlates to osteoporosis and fractures, independent of other conventional risk factors.
SPINA Team
