Having run Starfinder 2nd edition for well over a year at this point, I started during the playtest, I have to say, as a GM, I really like it.
I like the setting of Sci-Fantasy and how they’ve blended magic and tech. The silliness and humor are also a lot of fun to play with giving me the opportunity to jump between darker serious stuff and ridiculous stuff. The setting also made it easier for me to transition to Paizo’s 3action economy from DnD 5e.