#Retatrutide,
An experimental GLP-1 drug pushes the limits of weight loss.

There are risks.

Eli Lilly this month unveiled startling new data that showed an experimental weight-loss drug caused people with obesity to shed, on average, 28 percent of their body weight
— a substantial step up in potency from the existing crop of GLP-1 medicines.

But that breakthrough also is prompting some doctors to urge caution.

In interviews, doctors warned that using a drug to shrink your body that much will require close medical management
And — much more than the level of monitoring many people are now getting when taking drugs like Ozempic, Wegovy and Zepbound.

https://www.washingtonpost.com/health/2026/05/29/when-is-glp-1-drug-too-potent/

Trenta chili persi in due anni, il 28% del peso corporeo: i numeri (in fase 3) che Eli Lilly ha tirato fuori per retatrutide, il suo agonista triplo, sono i più alti mai visti da un farmaco dimagrante, e cominciano a sfiorare territori che finora erano roba da chirurgia.

La "guerra" farmaceutica tra farmaci dimagranti e solo all'inizio, e la posta in gioco è altissima. Ne faremo le spese (e/o ne beneficieremo) noi.

https://www.futuroprossimo.it/2026/05/retatrutide-numeri-da-record-per-la-terza-fase-dellanti-ozempic

#futuroprossimo #retatrutide #obesità

The Biochemical Beauty of Retatrutide: How GLP-1s Work

https://acesounderglass.com/2025/10/13/the-biochemical-beauty-of-retatrutide-how-glp-1s-actually-work/

#HackerNews #biochemistry #GLP1 #retatrutide #healthscience #drugdiscovery

Update: New Options for Weight Loss

The landscape of metabolic medicine is shifting beneath our feet. For the last few years, the conversation has been dominated by weekly injections like #Zepbound (#tirzepatide), #Wegovy (#semaglutide), #Foundayo (#orforglipron) and #retatrutide.

https://bit.ly/4sbhJVl
#obesity #WeightLoss

"Peptides may be milder than steroids, but, frankly, they take you out of the natty category."

#BPC157 #tb500 #Retatrutide #natty #naturalbodybuilding #FDAapproved

https://www.fitsavanna.co.ke/nutrition/are-you-still-natural-if-you-use-peptides-retatrutide-bpc-157-tb-500

Well this is a disturbing development, are the drugs we use what they seem?
I've seen how regulation has collapsed in America, I hope we're not following down that same Libertarian shit show?

https://www.theguardian.com/world/2025/oct/24/northampton-factory-making-counterfeit-weight-loss-jabs-raided

#Drugs #Medicines #UKCrime #retatrutide #tirzepatide

Watch out, Novo Nordisk. Lilly’s #retatrutide, a so-called triple G, has bettered not only Novo’s #Wegovy but Lilly’s own #Mounjaro when data from three different obesity trials are compared. The project allowed obese patients to lose nearly a quarter of their bodyweight after around a year’s treatment.

The downside was, as so often with incretins, side-effects, with 16% of patients in the high-dose group suffering so badly they withdrew from treatment.
#obesity
https://www.evaluate.com/node/18974/pdf

Wow!

Phase 2 data show 24% weight loss with triple-agonist retatrutide!

Key takeaways:

#Retatrutide, a triple-hormone agonist, was associated with 24.2% weight loss at the highest dose for people with #obesity.

The #GLP-1/#GIP/#glucagon agonist also reduced #HbA1c and body weight in type 2 #diabetes.

#lilly #mounjaro #ozempic #wegovy #weightloss
https://www.healio.com/news/endocrinology/20230626/this-raises-the-bar-phase-2-data-show-24-weight-loss-with-tripleagonist-retatrutide