Bart De Strooper presented at the Copenhagen AD/PD-conference an excellent sketch of the three main inflection points in the pathophysiological evolution of Alzheimer's disease, https://www.alzforum.org/news/conference-coverage/big-picture-three-inflection-points-mark-amyloid-cascade

My own transition from amyloid plagues to p-tau and tangles was retarded by a four years' anti-amyloid therapy in a clinical reaearch project during 2017-22 (aducanumab). Sadly, the most probable explanation for my rapidly worsening cognitive problems may indeed be the tau-tangles, which I somehow avoided earlier. I know there are experimental therapies around somewhere for those gremlins too, but sadly not within my own reach. With respect to my AD, I'm afraid, it's "too late, my friend".

I encourage anybody with a slowly lethal disease to keep mentally in touch with it as long as you can. That's what we human beings were made for. 🤗

#alzheimer #ad #at #disease #medical #amyloid #tau #lethal #sairaus #alzForum #realism #humanity #reflection #thinking #dying #terminallyill #metacognition #tietoisuus #consciousness

Breezing Up (A Fair Wind), Winslow Homer (1873 - 1876), https://etidiohnew.blogspot.com/2026/03/breezing-up-fair-wind-winslow-homer.html

#realism #art #paintings

📝 Plot: Young lovers Paul and Charlotte face the devastating news of her serious illness as they navigate fear, hope and shifting desires. When Charlotte’s cousin Ninon re‑enters their lives, Paul’s loyalty is tested. In this intimate drama of love and loss, the trio must confront the fragile boundaries between devotion, temptation and the brutal truths of life.

#LesCorpsImpatients #Drama #LoveAndLoss #Realism #FrenchCinema #Youth #Heartfelt #ComplexRelationships #Intimate

🎭 Cast: Laura Smet, Nicolas Duvauchelle, Marie Denarnaud, Catherine Salviat, Julien Bouvard, Maurice Antoni, Louis‑Do de Lencquesaing, Roman Rouzier, Catherine Ducerf, Manou Van Stipdonk, Alexandra Hojer, Rodrigue Grego…

#LesCorpsImpatients #sousTitres #cinemaFrançais #ensemble #FrenchCast #dramatic #ensemblefilm #actors #realism

🎬 Les corps impatients [Eager Bodies] (2003)

Subtitles available:
🇬🇧 English
🇫🇷 French
🇪🇸 Spanish

⬇️ Download https://app.box.com/s/x3v17rbxeysa10iw56wmdn6kn96h4eoh

🎞 IMDb https://www.imdb.com/title/tt0361474/

▶️ Watch the video here 👇
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#LesCorpsImpatients #Drama #FrenchFilm #LoveAndLife #XavierGiannoli #Heartache #Youth #Realism

📝 Plot: Young apprentice baker Esse quits his job in Orléans and heads to Marseille in search of a new life. After stealing money from a friend, he falls in with petty criminals around a boxing club. As he gets deeper into burglary and gang life he finds reality harsher than he expected, struggling with loyalty, identity and the brutal lessons of the streets…

#LePetitVoleur #Drama #Crime #ComingOfAge #FrenchCinema #Realism #Youth #GangLife #HardChoices

🎬 Le petit voleur [Smalltime Thief] (1999)

Subtitles available:
🇳🇱 Dutch
🇬🇧 English
🇮🇹 Italian
🇪🇸 Spanish

⬇️ Download https://app.box.com/s/xkzpekh3xz599g2hmitpwk1v3u0ykv7f

🎞 IMDb https://www.imdb.com/title/tt0184115/

▶️ Watch the video here 👇
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#LePetitVoleur #Drama #Crime #FrenchFilm #Realism #YouthStory #ErickZonca #OrleansMarseille

Read a high-level summary of the chapters in The Architecture of Encounter.

https://open.substack.com/pub/brywillis634737/p/the-architecture-of-encounter?r=pvxh5&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

When we're not writing, we may be performing ancillary activities like promotion and awareness. You are a witness. Video to follow. Do I need a new headshot?

#writing #philosophy #books #script #contents #ontology #logic #epistemoloogy #mediation #subjecthood #perception #language #socialontology #realism #normativity #SharingIsCaring #substack

When I went to my friend Bae's studio & gallery about a week ago, an #artist named Geng was working on this #portrait. He is making it for a family to give it to a local temple to be displayed inside.

#artists #art #arts #handmade #portrait #portraits #commissionsopen #spiritual #spiritiuality #illustration #realism #artwork #painting #paintings #nature #portraits #portraitartist #mastoart #artstodon #artistsonmastodon #commissions #artlover #artlovers #mastoart #artstodon #artistsonmastodon