New on ScienceOpen π
All International Conferences on #Pharmacometrics (ICoP) Series publications from 2025 are now live on ScienceOpen.
π Link to the 2025 ICoP Series publications in the first comment.
#Pharmacology #LifeSciences #QuantitativeBiology #OpenScience
π€ Why do we actually get a #fever? One reason is that immune cells move faster at higher temperatures. A team led by Stefan Wieser at the Institute of Zoology has now uncovered the molecular mechanism behind this process, with the motor protein myosin II taking center stage.
π https://www.uibk.ac.at/en/newsroom/heat-acts-as-a-turbo-boost-for-immune-cells/
π https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00636-7
#biology #cellularBiology #quantitativeBiology #molecularBiology #cellBiology #cellularBiology #cells #singleCellBiology
π€: arXiv q-bio.NC bot
@arXiv_qbioNC_bot
Joined: Dec 29, 2022
Bio: Quantitative Biology - Neurons and Cognition https://arxiv.org/list/q-bio.NC/new Not affiliated with arXiv. Run by @vela with https://github.com/so-okada/toXivOther bots: https://mastoxiv.page/@vela/109642387563304551You can filter by the keyword toXiv_bot_toot to hide all toXiv bot toots.#arXiv #QuantitativeBiology #NeuronsandCognitiontext-search: https://tootfinder.ch
ππͺ° Separated by evolution, connected by the same developmental code.
π Digital cousins: Simultaneous optimization of one model for BMP signaling in distant relatives reveals essential core. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.08.021
π CSBJ: https://www.csbj.org/
#BMPsignaling #DevelopmentalBiology #SystemsBiology #ComputationalBiology #EvolutionaryBiology #BiophysicalModeling #Bioinformatics #SyntheticBiology #QuantitativeBiology
6. 7/8 ππ Future prospects: there was so little biochemical data for our specific proteins, we had to rely on genome-wide data (PBMs). We could then estimate Kd for ANY sequence. That means, also for sequence variants.
Our earlier Framework Model v2 (FMv2) and FM-Life models link the clock right up, through plant metabolism, growth, development and physiology, to seed-to-seed adaptation in real weather.
Anyone who assembles these parts gets to predict how an Arabidopsis genome sequence variant will be adapted to climatic conditions. With a full causal chain. The mechanisms of evolutionary adaptation.π #GoForIt
Sure itβs simplified and thereβs much to validate but itβs there. DNA-binding Kd is just where we started, thereβs more known biochemistry to add.
Are you a graduate student or postdoc who wants to add novel developmental biology and biophysics methods to your research? Then have a look at #EMBLDevBio, where you'll learn all about highly multiplexed RNA fluorescent in situ hybridisation, quantitative imaging and analysis, machine learning based image segmentation, and more π₯Όπ
π₯ Apply by 26 March 2025
π https://s.embl.org/ptd25-01-ma
πΊοΈ EMBL Heidelberg
π
2 β 9 July 2025
Job - Alert π
π SEVEN PHD POSITIONS
Deadline: 2025-01-03
Location: Germany, Berlin
APPLY: https://www.academiceurope.com/job/?id=5964
#hiring #Biophysics #Epidemiology #Immunology #InfectionBiology #MedicalBiotechnology #Microbiology #Parasitology #PhD #quantitativebiology
It turns out it may be better to have (genetically) curly than straight hair (or no hair at all), π©π½β𦱠especially under extreme heat and/or sun exposure - shows a recent study by
@TinaLasisi
et al. π§¬
Tightly curled hair came off best in their experiment than other hair types (bald head, straight hair, moderately curled hair) regarding minimising sweating and overheating.
#Anthropology #biologicalanthropology #QuantitativeBiology #ComputationalBiology
https://nationalgeographic.com/premium/article/curly-hair-evolutionary-advantage-brain-protect
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