Does psilocybin really provide long-term relief from depression, as new study suggests?
Psilocybin may improve mood, social functioning, and life meaning in depression, comparable to escitalopram over six months, but small sample size and other treatments limit conclusions; further research is needed to confirm long-term effectiveness.
Research on Psilocybin and Depression - A Real Solution?
This article will highlight the research to reveal and explain why psilocybin has an effect on depression.
Psychedelic treatments are speeding towards approval — but no one knows how they work
https://www.nature.com/articles/d41586-023-03334-6
"...most scientists do think that psychedelic drugs promote brain plasticity, enabling the dendrites and axons that form neural circuits to diversify and make new connections."
#Psilocybin #psychedelictherapy #psychedelictreatments #magicmushrooms #psychedelic #psilocybinresearch #psilocybintherapy
Psychedelic treatments are speeding towards approval — but no one knows how they work
Many questions remain about the formerly taboo chemicals that are being used to treat trauma and depression.
Psilocybin and SSRIs: A Talk with Dr. Erica Zelfand, ND
https://psychedelic.support/resources/psilocybin-and-ssris
"Anecdotal evidence, along with one recent clinical trial, suggests that it’s safe to combine psilocybin with SSRIs."
- Psychedelic.Support, April, 2023
#Psilocybin #magicmushrooms #psilocybinresearch #psilocybinmushrooms #psilocybins #psychedelicmushrooms #psychedelictherapy #psychedelics
#psilocybintherapy
Psilocybin and SSRIs: A Talk with Dr. Erica Zelfand, ND
It's standard to wean SSRIs before beginning psilocybin therapy. But is it necessary? We sat down with Dr. Erica Zelfand to find out.
Duke Researchers Probe the Magic of Psychedelics as Medicine
https://medschool.duke.edu/stories/duke-researchers-probe-magic-psychedelics-medicine
“Do you need that psychedelic experience to achieve therapeutic effects? Or are you just putting a key in a biochemical lock, and it doesn’t matter if you’re conscious or not?"
#Psilocybin #magicmushrooms #psilocybinresearch #psilocybinmushrooms #psychedelictherapy #psychedelics
Duke Researchers Probe the Magic of Psychedelics as Medicine
Duke scholars are studying how hallucinogenic drugs might become alternative treatments for medical-resistant conditions.
Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication
https://www.nature.com/articles/s41386-023-01648-7
"..., post-hoc analyses revealing correlations between the intensity of altered or mystical state of consciousness and therapeutic outcome suggest that the acute psychedelic experience may play an important role."
--(published July, 2023)
#Psilocybin #magicmushrooms #psilocybinlover #psilocybinresearch #psilocybinmushrooms #psychedelictherapy #psychedelics
Psilocybin for treatment resistant depression in patients taking a concomitant SSRI medication - Neuropsychopharmacology
Psilocybin is being investigated as a treatment in adults with treatment-resistant depression (TRD). Withdrawal from serotonergic antidepressant drugs is a common prerequisite for taking part in trials of psilocybin due to the possibility of ongoing antidepressant drugs altering the psychedelic effect. This phase II, exploratory, international, fixed-dose, open-label study explored the safety, tolerability, and efficacy of a synthetic form of psilocybin (investigational drug COMP360) adjunct to a selective serotonin reuptake inhibitor in participants with TRD. Participants received a single 25 mg dose of psilocybin alongside psychological support and were followed-up for 3 weeks. The primary efficacy end point was change in the Montgomery-Åsberg Depression Rating Scale (MADRS) total score from Baseline at Week 3. Secondary end points were safety, including treatment-emergent adverse events (TEAEs), the proportion of responders and remitters at Week 3, and the change from Baseline to Week 3 in Clinical Global Impression–Severity (CGI-S) score. Nineteen participants were dosed and the mean Baseline MADRS total score was 31.7 (SD = 5.77). Twelve (63.2%) participants had a TEAE, most of which were mild and resolved on the day of onset. There were no serious TEAEs or indication of increased suicidal ideation or behavior. At Week 3, mean change from Baseline in MADRS total score was −14.9 (95% CI, −20.7 to −9.2), and −1.3 (SD = 1.29) in the CGI-S. Both response and remission were evident in 8 (42.1%) participants. Larger, comparator-controlled trials are necessary to understand if this paradigm can optimize treatment-outcome where antidepressant drug withdrawal would be problematic.
Legal Psilocybin Edibles Could Be Coming to Colorado
https://www.westword.com/marijuana/legal-psilocybin-edibles-could-be-coming-to-colorado-18057553
"Magic mushroom chocolates, gummies, tea and other psilocybin edibles could be legally available in Colorado by late 2024 or early 2025, according to the state Department of Revenue's new Natural Medicine Division."
#Psilocybin #magicmushrooms #psilocybinlover #psilocybinresearch #psilocybinmushrooms #psilocybins #psychedelicmushrooms #psychedelictherapy #psychedelics
Legal Psilocybin Edibles Could Be Coming to Colorado
There are some catches, but state regulators are open to the idea.
Exciting new research into psilocybin suggests that it could hold the key to treating major depression. Psilocybin desynchronizes key brain networks, including the default mode network, which could explain how it achieves its therapeutic effects. The network desynchronization persisted for weeks after treatment but resolved after six months. This breakthrough research offers hope for those suffering from depression. #PsilocybinResearch #DepressionTreatment #BrainScience
https://www.iflscience.com/psilocybin-desynchronizes-important-brain-networks-and-it-could-explain-its-antidepressant-effects-70418?utm_source=flipboard&utm_content=HariTulsidas%2Fmagazine%2FMind+and+Matter#:~:text=Psilocybin%2C%20the%20psychoactive%20c
Psilocybin Desynchronizes Important Brain Networks And It Could Explain Its Antidepressant Effects
The findings in a new preprint could help explain how single doses can have lingering effects.
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