🧬 Ubiquitin Precursor: A Key to Healthy Aging?
Researchers from the #UniCologne and the Heinrich-Heine-Universität Düsseldorf have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging. This discovery opens up potentially new perspectives for the treatment of cancer and age-related diseases.
Read more ▶️ https://uni.koeln/BLXJA
📰 https://www.sciencedirect.com/science/article/pii/S1097276525007373
#uniköln #unicologne #Research #Ubiquitin #Cancer #Aging #Health #proteostasis
Hi #ScienceMastodon! I am happy to share the final #ResearchHighlight from Issue 18 of JCS. Song-Kun Shyue and colleagues at the Institute of Biomedical Sciences, Academia Sinica, Taiwan, unravel the upstream protein machinery required for ER-associated degradation (ERAD) of the crucial enzyme cyclooxygenase-2.
#cellbiology #proteostasis
Derlins and Surf4 work together to ERADicate COX-2
https://journals.biologists.com/jcs/article/136/18/e136_e1804/330714/Derlins-and-Surf4-work-together-to-ERADicate-COX-2
Derlins and Surf4 work together to ERADicate COX-2
Cyclooxygenase-2 (COX-2) is a crucial enzyme in the synthesis of eicosanoids, signalling molecules that regulate a broad array of physiological processes. COX-2 is dynamically regulated in response to many hormones, growth factors and cytokines, which can require accelerated degradation of COX-2 via ER-associated degradation (ERAD). ERAD involves retrotranslocation of ER-resident proteins and extraction by the ATPase p97 prior to proteasomal degradation. Although diverse factors involved in retrotranslocation and ERAD have been described, degradation of many ER-resident proteins requires specific combinations of factors that have not been defined. Here (Chen et al., 2023), Song-Kun Shyue and colleagues investigate the ERAD machinery involved in COX-2 degradation and identify the ER membrane proteins derlin-1, derlin-2 and Surf4 as facilitators of COX-2 degradation upstream of p97. By carefully assessing protein–protein interactions, the authors resolve the sequential requirement of derlin-2, derlin-1, Surf4, caveolin-1 and p97 for efficient COX-2 degradation. Whereas degradation of COX-2 is dependent on its N-glycosylation state, its interaction with this ERAD machinery occurs regardless of glycosylation. Surf4, which typically regulates ER protein secretion, represents an unexpected player in this ERAD machinery. Taken together, these findings uncover a unique degradation pathway for COX-2 that might contribute to its dynamic and rapid regulation.
New paper! Great collaboration between our group and the @mz at @biozentrum @unibasel - supported by a Sinergia grant of the @snsf_ch.
Aberrant #proteostasis (balance between protein synthesis and degradation, centrally regulated by #mTOR) and mitochondrial dysfunction are two of the most prominent and reproducible processes associated with #aging in skeletal #muscle (and other tissues).
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https://www.pnas.org/doi/10.1073/pnas.2302360120
Postdoctoral Research Fellow in Proteostasis and Aging
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PhD in Ubiquitin and Immune Signalling
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Check out the latest paper from my buddy @TheVilchezLab on aging. The third paper today from my smart friends! V r doing well.
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RT @TheVilchezLab
New work from the lab @NatureAging!❄️Lowering body temperature extends
#longevity. We find that cold-induced
#proteostasis prevents
#aging and aggregation of proteins that cause age-related diseases
#ALS #HuntingtonDisease in C. elegans and human cells
https://www.nature.com/articles/s43…https://twitter.com/TheVilchezLab/status/1642908783327207426Another neat worskhop @DGZ_info, talks by @IgnatovaLab @FranziskaOttens @_ilgink @TheVilchezLab.
I loved the story ER associated degradation & the "smurf assay" in #celegans by @Soto_Ef @FranziskaOttens, Shutter, et al.
Full: https://www.nature.com/articles/s41556-022-01025-4 #ER_literature #scicomm
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RT @DGZ_info
Join us for the next #DGZ Focus Workshop on Cellular and Organismal #Proteostasis on March 28, featuring @_ilgink, @TheVil…
https://twitter.com/DGZ_info/status/1633025784968359943
ER-associated RNA silencing promotes ER quality control - Nature Cell Biology
Efstathiou et al. describe an Argonaute-dependent endoplasmic reticulum (ER)-associated RNA silencing pathway that acts together with ER-associated protein degradation to preserve ER homeostasis and function.
Targeting the mitochondria-proteostasis connection in ageing and disease | Dr Vincenzo Sorrentino
We now have an official departmental page for the Charlotte Group for Proteostasis Research (biology.charlotte.edu/research/prote…)! Keep an eye out for possible opportunities to join us in the future 😀
#proteostasis #chaperones @UNCCBiology
Maximilian A. Thompson and Evandro A. De-Souza review recent advances in the intersection of #proteostasis and #aging, with a particular focus on new understanding of how cells communicate with each other during #proteotoxic stress. #Review 🔍 #OpenAccess 🔐
https://journals.biologists.com/bio/article/12/2/bio059750/287042/A-Year-at-the-Forefront-of-Proteostasis-and-Aging
#Biology #Science #BiologyOpen #AcademicMastodon
Year at the Forefront of Proteostasis and Aging
Summary: This A Year at the Forefront Review summarises key findings and new datasets in the intersection of proteostasis and aging, with a focus on articles and preprints published between November 2021 and October 2022.
Universität zu Köln
Amelia Glazier
Christoph Handschin
jobRxiv
Kurianlab
Pablo J. Sáez 
Andy Truman PhD
Biology Open