Structural investigations of unliganded murine KHK-A revealed the adoption of two conformations similar to those adopted by the human ortholog, suggesting this structural feature is conserved across species
#PfkBFamily #Moonlighting #ProteinKinases https://doi.org/10.1107/S2053230X25008428.@Moon_Synth_Bio &co show that cellular thermogenesis in
#Ecoli is regulated by the
#ProteinKinases ArcB, GlnL and YccC, and is related to cellular ATP concentrations;
#thermogenesis can be engineered by overexpressing GlnL
#PLOSBiology https://plos.io/3s7XdMc
Microbial thermogenesis is dependent on ATP concentrations and the protein kinases ArcB, GlnL, and YccC
This research advances microbiology by shifting the paradigm of metabolic heat generation. We identified heat regulators and demonstrated a correlation between ATP concentrations and a microbial cell’s ability to generate excess heat for the first time.
StructBiolCommunications
Cytology and Genetics
PLOS Biology