Cool new #PNN paper: PNNs regulate excitatory input on PV+ cells (in NAc at least):

The Perineuronal Net Protein Brevican Acts in Nucleus Accumbens Parvalbumin-expressing Interneurons of Adult Mice to Regulate Excitatory Synaptic Inputs and Motivated Behaviors
Hazlett et al., Biological Psychiatry 2024
https://doi.org/10.1016/j.biopsych.2024.02.003

#neuroscience #parvalbumin #GABAergic

Interesting perineuronal net (#PNNs) and #extracellular_matrix labelling strategy - knock in a fluorescent protein into the linker protein. Super promising for anyone looking into #parvalbumin #GABAergic neuronal anatomy.

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivo
Lemieux et al., #preprint at biorxiv 2023
https://doi.org/10.1101/2023.11.29.569151

#neuroscience

What modulates the output of #cortical #parvalbumin-positive #neurons in the mature #brain?

Kai-Wen He and colleagues reveal rhythmic time- and sleep-dependent regulation via #synaptic M1 #acetylcholine receptors in the mouse primary visual cortex

https://www.embopress.org/doi/10.15252/embj.2022111304