Researchers reveal molecular mechanism of pannexin 2 as ATP membrane pore channel
A research team led by Prof. Yuan Shuguang from Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences and Prof. Zhang Huawei from the South University of Science and Technology has revealed the molecular mechanism of pannexin 2 (Panx2) as an ATP membrane pore channel.
#Astrocytes mostly seem to *boost* neuronal activity, but @elena_dossi @NathalieRouach &co reveal that activity-dependent activation of astroglial
#pannexin 1 channels *inhibits* hippocampal
#neuronal networks - a novel negative feedback loop
#PLOSBiology https://plos.io/3h65tXQ 
Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns
Astrocytes have mostly been shown to boost neuronal activity. This study reveals that activity-dependent activation of astroglial pannexin 1 channels inhibits hippocampal neuronal networks by decreasing neuronal excitability via purinergic signaling, uncovering a novel astroglial negative feedback loop mechanism.
#Astrocytes mostly seem to *boost* neuronal activity, but @elena_dossi @NathalieRouach &co reveal that activity-dependent activation of astroglial
#pannexin 1 channels *inhibits* hippocampal
#neuronal networks - a novel negative feedback loop
#PLOSBiology https://plos.io/3h65tXQ Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns
Astrocytes have mostly been shown to boost neuronal activity. This study reveals that activity-dependent activation of astroglial pannexin 1 channels inhibits hippocampal neuronal networks by decreasing neuronal excitability via purinergic signaling, uncovering a novel astroglial negative feedback loop mechanism.
#Astrocytes mostly seem to *boost* neuronal activity, but @elena_dossi @NathalieRouach &co reveal that activity-dependent activation of astroglial
#pannexin 1 channels *inhibits* hippocampal
#neuronal networks - a novel negative feedback loop
#PLOSBiology https://plos.io/3h65tXQ Pannexin 1 activity in astroglia sets hippocampal neuronal network patterns
Astrocytes have mostly been shown to boost neuronal activity. This study reveals that activity-dependent activation of astroglial pannexin 1 channels inhibits hippocampal neuronal networks by decreasing neuronal excitability via purinergic signaling, uncovering a novel astroglial negative feedback loop mechanism.
The findings of this study open up possibilities for further research on the role of ATP in apoptosis, as well as potential therapeutic targets for controlling cell death.
#ATP #Cell #CellDeath #Apoptosis #Caspase-3 #Pannexin-1 #Metabolism #FRET #Biosensors
CellBioNews
PLOS Biology
Joseph P.