My #PanCholLiveToot friends, I just got some very good news!
No cholera vaccine bacteria were detected in yesterday's sample. This is good for me personally and for the #PanChol vaccine in general.
For me personally, it means there's a good chance I'll be able to go home before the weekend. If today's sample comes back clean tomorrow, then they'll probably start me on prophylactic doxycycline tomorrow and send me home Friday.
(continued)
Here we go for round two of #PanCholLiveToot! I'm in a Lyft on my way to Brigham & Women's Hospital for my second inpatient stay to participate in a clinical trial for a revolutionary cholera vaccine called #PanChol. Catch up on the last chapter at https://blog.kamens.us/2025/09/04/panchol-clinical-trial-thread-unroll/. Follow along at #PanCholLiveToot as I post about the experience.

“PanChol” clinical trial thread unroll

In October and November 2024, I participated in a clinical trial for a cholera vaccine called “PanChol” being developed at Boston’s Brigham & Women’s Hospital (a.k.a. Mass General Brigham). Current cholera vaccines are expensive and not very effective and difficult to distribute and administer because they have strict temperature storage requirements and are injected rather than given orally. In contrast, the PanChol vaccine is given orally, and the doctors developing it believe they will be able to make it shelf-stable to be rehydrated on-site.

During the trial I had to stay in the hospital for about a week in isolation. I “live-tooted” about my stay on Mastodon. Those posts have scrolled off of everyone’s feed, so I thought it would be a good idea to capture them here, because I’m about to participate again in the next phase of the clinical trial which I’ll be posting about. I wanted to make it easy for people who are curious to go back and look at what I posted before, especially since a I subsequently deleted a couple of posts in the thread to free up space on the server so the thread isn’t contiguous when you view it in the fediverse.

Below, therefore, are all my posts with the “#PanCholLiveToot” hashtag before today.

https://federate.social/@jik/113385768267486863

https://federate.social/@jik/113385827145137752

https://federate.social/@jik/113385949805187032

https://federate.social/@jik/113385964038084019

https://federate.social/@jik/113386006517341852

https://federate.social/@jik/113386031992291779

https://federate.social/@jik/113386053192915945

https://federate.social/@jik/113386076291635900

https://federate.social/@jik/113386134657061712

https://federate.social/@jik/113386182255222135

https://federate.social/@jik/113386198277860129

https://federate.social/@jik/113386232627375377

https://federate.social/@jik/113386257290593978

https://federate.social/@jik/113386615817815890

https://federate.social/@jik/113386630153673751

https://federate.social/@jik/113386652590260059

https://federate.social/@jik/113386697495508206

https://federate.social/@jik/113387190475691646

https://federate.social/@jik/113387191709149227

https://federate.social/@jik/113387238096635506

https://federate.social/@jik/113390494205867631

https://federate.social/@jik/113390788734605108

https://federate.social/@jik/113396558266945482

https://federate.social/@jik/113403017910706067

https://federate.social/@jik/113403026215960042

https://federate.social/@jik/113403031659784213

https://federate.social/@jik/113403043672831863

https://federate.social/@jik/113403071480609170

https://federate.social/@jik/113407805990692740

https://federate.social/@jik/113407841630549472

https://federate.social/@jik/113408574762529783

https://federate.social/@jik/113410473174217460

https://federate.social/@jik/113413964488963810

https://federate.social/@jik/113414002326890114

https://federate.social/@jik/113414016586114260

https://federate.social/@jik/113414037027571298

https://federate.social/@jik/113414044369582349

https://federate.social/@jik/113414058388673871

https://federate.social/@jik/113414065537916664

https://federate.social/@jik/113414183368438218

https://federate.social/@jik/113415633468159697

https://federate.social/@jik/113415662147124239

https://federate.social/@jik/113415685851142372

https://federate.social/@jik/113415700797873217

https://federate.social/@jik/113415762826943777

Deleted post from the thread resurrected from my backup:

“Several people at work this week have commented to me that the room I’m in looks like something out of 2001: A Space Odyssey. People in the thread here have commented as well. It’s even more true when I’m on Meet / Teams / Zoom and I turn on background blurring:”

https://federate.social/@jik/113415879316539727

https://federate.social/@jik/113415891209286993

https://federate.social/@jik/113415908400419490

https://federate.social/@jik/113419905989936266

Deleted post from the thread resurrected from my backup:

“Free at last, and already failing to follow the doctor’s instructions to use sunblock until a couple days after I finish the antibiotics (doxycycline causes sun sensitivity). I did not bring sunblock with me to the hospital six days ago. 😉 Waiting for the bus. Could have taken a Lyft that they would have reimbursed me for, but does the kind of person who volunteers for clinical trials take a Lyft when there’s perfectly good public transit? No, he does not.”

https://federate.social/@jik/114265543197475183

https://federate.social/@jik/114265544292941615

https://federate.social/@jik/114265552936138377

https://federate.social/@jik/114926896103129335

https://federate.social/@jik/114926903879889071

#BrighamWomenSHospital #cholera #clinicalTrials #MassGeneralBrigham #PanChol

Followup about the #PanChol clinical trial I participated in back in April: the study was just unblinded, so I now know that I was given the vaccine, not a placebo.
They want me to participate in a followup booster study, which will again involve an inpatient hospital stay albeit hopefully a shorter one. I told them I couldn't commit to that right now—feeling rather overwhelmed in general at the moment—but they should check back in September and things might be better then.
#PanCholLiveToot
A final update about the #PanChol cholera vaccine clinical trial which I participated in, spending a week in the hospital as described in the above thread…
This morning was my final appointment for the trial. I dropped off one last home-collected stool sample (ugh!), had a few vials of blood drawn, and was on my way. This was the last of three such visits after the inpatient stay.
#PanCholLiveToot
🧵1/3
This is the room I'm trapped in for the next week while participating in a #clinicalTrial for a potentially revolutionary #cholera vaccine called #PanChol invented here at Brigham & Women's hospital (#BWH) in #Boston. I'll basically be doing my regular job all week while helping save lives.
I'm in isolation because if I were to shed the vaccine and somebody else picked it up from me it could cause a false cholera outbreak panic.
I'll be posting about my experience under #PanCholLiveToot. #AMA!