PROTACs que degradan KRAS provocan regresión tumoral profunda y duradera en modelos de cáncer de pulmón, superando a inhibidores y resistencias (Cancer Research). https://aidoo.news/noticia/rvXBw2

#Oncologia #PROTAC #Investigacion #Ciencia #España

PROTACs que degradan KRAS provocan regresión tumoral profunda y duradera en modelos de cáncer de pulmón, superando a inhibidores y resistencias (Cancer Research). https://aidoo.news/noticia/rvXBw2

#Oncologia #PROTAC #Investigacion #Ciencia #España

Amazing news that the first #PROTAC for targeted protein degradation has been approved by the FDA. Great to see an entirely new modality added to the therapeutic toolbox.

https://news.yale.edu/2026/05/07/yale-led-technology-receives-fda-approval-breast-cancer-treatment

Very curious to see, how the field of induced proximity will develop further into the future with so many additional exciting applications already shown in basic academic research. Curious, which other therapeutic areas will most profit from this development. (1/2)

PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8

#drugdesign #chemistry #MedicinalChemistry #research #science

🤖 Can AI help us predict and prevent off-target effects in PROTAC drug design?

🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028

📚 CSBJ: https://www.csbj.org/

#DrugDevelopment #StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery #Cheminformatics #Bioinformatics #PrecisionMedicine #TargetedProteinDegradation

🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.

🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling

AI Breakthrough By UW Scientists Targets ‘Undruggable’ Proteins, Paving Path to Novel Therapies.

#UndruggableNoMore, #AIDrugDiscovery, #PROTAC, #TargetedProteinDegradation, #UWMedicine, #CancerTherapy, #AlzheimersResearch, #MedicalBreakthrough,

https://medium.com/@jckapadia003/ai-breakthrough-by-uw-scientists-targets-undruggable-proteins-paving-path-to-novel-therapies-47b78c5db519

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97619

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97619

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97290

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97290