PKMYT1 is a promising target for #cancer #drug developmenent. While some inhibitors such as RP-6036 are available for some time, researchers from InSilico #Medicine have now introduced a novel #PROTAC degrader based on their computational design of a novel inhibitor. This study was now published in #Nature Communications (2025):
https://www.nature.com/articles/s41467-025-65796-8

#drugdesign #chemistry #MedicinalChemistry #research #science

🤖 Can AI help us predict and prevent off-target effects in PROTAC drug design?

🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028

📚 CSBJ: https://www.csbj.org/

#DrugDevelopment #StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery #Cheminformatics #Bioinformatics #PrecisionMedicine #TargetedProteinDegradation

🧩 The future of drug discovery may depend on how well we understand PROTAC-driven protein partnerships.

🔗 Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2023.02.049

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #PROTAC #DrugDiscovery #ComputationalBiology #ProteinEngineering #ProteinDegradation #Biopharma #MedicinalChemistry #TargetedTherapies #AIinBiotech #MolecularModeling

AI Breakthrough By UW Scientists Targets ‘Undruggable’ Proteins, Paving Path to Novel Therapies.

#UndruggableNoMore, #AIDrugDiscovery, #PROTAC, #TargetedProteinDegradation, #UWMedicine, #CancerTherapy, #AlzheimersResearch, #MedicalBreakthrough,

https://medium.com/@jckapadia003/ai-breakthrough-by-uw-scientists-targets-undruggable-proteins-paving-path-to-novel-therapies-47b78c5db519

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97619

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97619

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97290

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97290

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97031

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=97031

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96653

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96653

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96527

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96527

Postdoctoral Fellow

Ruijin Hospital

The new Frontiers in Therapeutics Research Laboratory is an exciting opportunity to launch your career in translational research.

See the full job description on jobRxiv: https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96324

#Cancer_Pharmacology #cell_biology #lnp_mrna #protac #ScienceJobs #hiring #research
https://jobrxiv.org/job/ruijin-hospital-27778-postdoctoral-fellow/?feed_id=96324