Oral PCSK9 Inhibitor Enlicitide Reduces LDL Cholesterol by Approximately 60% in Phase 3 Trial

📰 Original title: New pill cuts “bad” cholesterol by 60% in major trial

🤖 IA: It's clickbait ⚠️
👥 Usuarios: It's clickbait ⚠️

View full AI summary: https://killbait.com/en/oral-pcsk9-inhibitor-enlicitide-reduces-ldl-cholesterol-by-approximately-60-in-phase-3-trial/?redirpost=cee93522-b80d-43fc-aa95-396287d3e6e5

#health #cholesterol #pcsk9inhibitor #clinicaltrial

Today is Rare Disease Day.

I've got two of those.  

First is familial hypercholesterolemia. This is not your run--of-the-mill hypercholesterolemia. No. This cannot be just treated with diet and exercise. Even the statins aren't great at treating it. The state of the art is a PCSK9 inhibitor. This, this does wonders.

Then, there's the PCNS lymphoma. Lymphomas are already considered rare. The PCNS form is even rarer. I'm over 5 years in remission and doing fine.

May we eradicate all diseases, from the commonest to the rarest.

#RareDiseaseDay2026 #RareDiseaseDay #hypercholesterolemia #FamilialHypercholesterolemia #PCSK9Inhibitor #lymphoma #cancer #PCNSLymphoma #CancerSurvivor #HeartAttackSurvivor

I just had my annual meeting with my lipid specialist. My cholesterol is fine.

We're moving from praluent to repatha for my PCKS9 inhibitor, but that's due to the insurance company, not because I'm doing badly.

#cholesterol #FamilialHypercholesterolemia #LipidSpecialist #PCSK9Inhibitor

It's finally come to this...

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Today is the day I shoot myself....

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With my PCSK9 inhibitor, a drug I shoot myself with every two weeks to keep my cholesterol in check.  

You, too, can... Wait...  Never mind, my condition is genetic.

#FamilialHypercholesterolemia #PCSK9Inhibitor #genetics

I had a praluent delivery scheduled for delivery on Friday last week, but UPS delayed it until Monday of this week.

Praluent needs refrigeration.

By the time it got here, it wasn't refrigerated anymore. The ice packs it was packed with had melted long before it got here.

I send a message to my pharmacy on Monday evening. They contacted me by phone today.

A replacement is going to be shipped.

#PCSK9Inhibitor #praluent #FamilialHypercholesterolemia #medicine #pharmacy #UPS #fuckup #refrigeration

OMG! I shot myself!

"How did you do that?"

I put it against my left arm and squeezed the trigger.

"Are you okay?"

Yes. It stung a bit, and I bled a tiny bit.

"Wait? What did you shoot yourself with."

My PCSK9 inhibitor.

"What does it do?"

It inhibits the PCSK9.

"Oh..."

#PCSK9Inhibitor #FamilialHypercholesterolemia

Yay! Another problem that resolved itself.

My order for my PCSK9 inhibitor is being processed. The last I checked, they wanted a prescription. I was going to get on the horn today if the status had not improved.

I won't get to go feral!

(Yes, that's what happens when I run out of meds. I don't just become non-compliant. I go feral!)

#PCSK9Inhibitor #feral #noncompliant

OMG! I shot myself!

"What happened?"

I shot myself with my alirocumab.

"Your ali-what?"

My praluent.

"Your what?"

My PCSK9 inhibitor.

"What does it do?"

As the name says, it inhibits the PCSK9.

"What's the PCSK9?"

Hell if I know. A protein, I guess.

"What's a protein?"

Did you fail biology class?

"Yes."

Well...

#PCSK9inhibitor #alirocumab #praluent #FamilialHypercholesterolemia #hypercholesterolemia #protein #biology

So, yesterday I got a letter from #AARP #MedicareRx which is powered by #UnitedHealthcare that my PCSK9 inhibitor needs reauthorization. They "gallantly" covered a month of supply.

Well, that's because the terrible US healthcare system requires this of them. Otherwise, they'd leave me high and dry.

I sent a message to my lipid specialist this morning.

I'm going to say it again: most of the time, when a patient because noncompliant, that's because of our shitty healthcare system.

#PCSK9inhibitor #LipidSpecialist #USHealthcare #USHealthInsurance #noncompliant

Here's a good example of how the US health care system is messed up.

I have a genetic defect. This defect causes hypercholesterolemia. So I have what is called *familial* hypercholesterolemia, because the cause is my genes.

I've been approved for a PCSK9 inhibitor. This is a drug that works only for people who have familial hypercholesterolemia. If you give it to a random guy without my disease, it is going to do nothing to them. (Perhaps hurt them, I'm not sure.)

I've received a letter from my health insurance saying that my approval is expiring soon.

Why?  

This is a genetic defect. A PCSK9 inhibitor is not gene therapy. It does not modify my genetic makeup. That's why I have to keep taking this drug.

Because it is a genetic defect, I'm going to have to be on this drug until I die. Or maybe they are going to find something better, but I expect this "something better" will also require approval because we're wading into highly specialized territory here.

So, again, why ask for approvals every year? It is not like my genetic code is going to fix itself magically.

#PCSK9Inhibitor #USHealthcare #healthcare #approval #hypercholesterolemia #genes #GeneticDefect