Cytology and GeneticsFeb 4, 2025
Plant Histone Deacetylases: Their Classification and Inhibitor Search - #histonedeacetylases #Arabidopsisthaliana #Oryzasativa #homologyclassification #moleculardocking #inhibitors #histone #Arabidopsis #Oryza - https://link.springer.com/article/10.3103/S0095452724050116
Plant Histone Deacetylases: Their Classification and Inhibitor Search - Cytology and Genetics

Abstract Histone deacetylases is a family of enzymes pivotal in regulating numerous crucial cellular processes in both plant and animal cells. Plant histone deacetylases have been considerably less investigated in comparison to their human counterparts. This study aims to provide an in-depth characterization of histone deacetylases in two model plant proteins-species Arabidopsis thaliana and Oryza sativa. Phylogenetic analysis of their relationship to known human homologs has revealed their close relation to three classes of human histone deacetylases. Notably, the highest sequence homology among histone deacetylases from different evolutionary origins was observed between human HDAC6 and A. thaliana HDA5 (43.6% homology). Structural alignment results highlighted the conservation of catalytic domains and demonstrated a high activity of inhibitors against both histone deacetylases. Ligand-protein docking studies suggested a high potency of human histone deacetylase inhibitors against A. thaliana HDA5. These findings suggest the potential efficacy of human histone deacetylase inhibitors in modulating plant histone deacetylases, thereby enhancing growth regulation, development, and stress resistance in plants.

SpringerLink
CellBioNewsJan 22, 2024

#Chromatin modifier-centered pathway points to higher #crop yield.

#transcriptomics #bZIP23 #HHC4 #Oryza

https://phys.org/news/2024-01-chromatin-centered-pathway-higher-crop.html

Chromatin modifier-centered pathway points to higher crop yield

A team led by Prof. Song Xianjun from the Institute of Botany of the Chinese Academy of Sciences, while researching a ternary protein complex in rice nuclei that affects grain size, has shown that the transcription factor bZIP23—a protein that regulates the transcription of genetic DNA information into RNA and is part of the ternary complex—recruits the chromatin-modifying histone acetyltransferase HHC4 to specific promoters on the DNA.

Phys.org
JIPBMar 3, 2023
Over here at #JIPB, we're on a roll--a leaf roll!
Zhou et al. reveal new insights into the molecular mechanisms underlying #leaf rolling in #rice
https://doi.org/10.1111/jipb.13460
@wileyplantsci
#PlantScience #CropScience #plant #development #ESCRT #Oryza
JIPBFeb 28, 2023
February getting you down? Over here at #JIPB, we're on a roll--a leaf roll!
Zhou et al. reveal new insights into the molecular mechanisms underlying #leaf rolling in #rice
https://doi.org/10.1111/jipb.13460
@wileyplantsci
#PlantScience #CropScience #plant #development #ESCRT #Oryza
KlimagartenSep 23, 2022
Manchmal hilft ein ruppiges Umtopfen. Vom viel zu großen Wasserfass in was kleines, damit ichs auch vor dem Frost nach Hause fahren kann. Vielleicht gefällt ihm auch nur die Ruhe hinter dem Fenster. Der #Reis (#Oryza sativa) treibt endlich die erste Ähre!