Researchers Develop Light-Controlled Protein Evolution for Dynamic Cellular Functions
📰 Original title: Light-guided evolution creates proteins that can switch, sense, and compute
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View full AI summary: https://killbait.com/en/researchers-develop-light-controlled-protein-evolution-for-dynamic-cellular-functions/?redirpost=71441d18-9f49-49b4-831d-11648d343df8
#Zhongmou wins U.S. #FDA clearance for China's first optogenetic human trials https://www.linkedin.com/pulse/zhongmou-wins-us-fda-clearance-chinas-first-optogenetic-k1vte/ using ZM-02 for treating advanced retinitis pigmentosa; #RP #blindness #opsin #optogenetics #PRISM
"By bypassing damaged rod and cones, this mutation-agonistic approach is being developed for advanced retinal diseases, including retinitis pigmentosa and geographic atrophy (GA) in age-related macular degeneration."
Adam Claridge-Chang and Shiqiang Gao analyse K+ channelrhodopsins:
"both the absolute K+ to Na+ permeability ratio and its stability over time determine the inhibition to activation transition, which limits their utility for silencing neural circuits."
And they found that a single aminoacid mutant, KCR1-C29D, "shows a relatively high and the most stable K+ to Na+ permeability ratio during illumination", better than heavily protein engineered versions.
"Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins", Duan et al. 2025
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202509180
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