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2025-08-04 10:45:05 CEST
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Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants

Increased Orf6 levels suppressed host innate responses to infection by decreasing IRF3 and STAT1 signalling

Our data suggest that convergent evolution of enhanced innate immune antagonist expression is a common pathway of human adaptation and improved innate immune evasion.

SEE ALSO
https://x.com/ravenscimaven/status/1749630379936346559?s=20

https://commons.wikimedia.org/wiki/File:SARS-CoV_genome_organization.jpg

#Orf6

https://www.nature.com/articles/s41564-023-01588-4