🕵️ AlphaFold 2 predicts stability—but life runs on flexibility. Are we missing half the story?

🔗 Bridging prediction and reality: Comprehensive analysis of experimental and AlphaFold 2 full-length nuclear receptor structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.010

📚 CSBJ: https://www.csbj.org/

#AlphaFold2 #DrugDiscovery #AIinBiology #StructuralBiology #NuclearReceptors

An #introduction while I dip my toe in the Mastodon waters...

I'm a cancer researcher in Colorado and principal investigator for the Sikora Lab (sikoralab.com). We study #estrogenreceptor biology, focusing on ER in #lobular #breastcancer and gynecologic cancers. My PhD is in #pharmacology, which fuels an interest in anti-estrogen therapeutics. I also co-lead a #nuclearreceptors collaborative group, NR IMPACT (nrimpact.com).

I run on caffeine and snark.

#cancerresearch #science #scicomm #PhD