Ever had one of those moments? You’re cruising along, maybe a little lost in thought, and then – BAM! – a sudden loud noise, or a near-miss on the sidewalk. #alertness #bloodpressure #fightorflight #neurotransmitter #Noradrenaline #Norepinephrine #stresshormone
Noradrénaline 🤩💛☀️🤓
Nouvvelle collec bijoux 🥳
#hormones #neurobordel #neurobazar #adhd #neurosciences #neurodivergent #neurodiversity #tdahadulte #tdah #tsa #noradrenaline
#bijoudujour #miyuki #miyukibeads #bracelets #bracelet #miyukidelica #tissagedeperles #doityourself #handmade #handmadejewelry #handmadewithlove
Hey folks 👋
For those who don't already know, we're currently signed off work due to depression, anxiety, and burnout.
Our employer is supportive, but there are multiple, fundamental, ongoing issues with the organisation that no amount of individual support can resolve. We cannot go into more detail.
During the last 2 and a bit weeks, we've done a mixture of resting and doing tasks we've been meaning to do for ages, but neither had the time nor spoons to do.
We're still on 200 mg sertraline (an SSRI) daily, but we've made the switch from taking 150 mg bupropion (an NDRI) daily alongside to 40 mg atomoxetine (an sNRI, not an SNRI) daily alongside. We're slowly titrating up to the recommend 80 mg dose.
As we came off the bupropion steadily, we definitely felt it (i.e., mood; executive function; energy etc.), but the effects are levelling off as our atomoxetine dose steadily increases.
The bupropion had helped us for a while, both with our mental health and some ADHD struggles, but could only do so much. As such, we decided to make the unorthodox switch to atomoxetine.
Bupropion is an atypical NDRI and antidepressant: it boosts noradrenaline and dopamine (to a lesser extent). However, it's only prescribed off licence for ADHD, as it's not been shown to be effective. Atomoxetine, conversely, is mainly used to treat ADHD in people who do not respond well to stimulants, such as methylphenidate. It directly boosts noradrenaline and indirectly boosts dopamine in the prefrontal cortex by a decent amount.
Since we do not tolerate any stimulants well (even caffeine), atomoxetine is our best bet in terms of an ADHD med that also helps with our mental health.
Unlike bupropion, it doesn't have any major interactions with sertraline (only moderate), and we can take 40 mg propranolol tablets alongside to help keep our anxiety under control, rather than turning straight to 10 mg diazepam tablets.
So far, we're doing well with the switch, both physically and mentally, but it'll be a while before we know for sure whether this the ideal medication combination.
We are still very much in low power recovery mode, so don't expect anything much or consistent from us.
A last note to sign this off: from the above listed drugs, the only one we can currently get via the NHS is sertraline. We may be able to get atomoxetine through the NHS in the future, but that's dependent on us ever actually getting a formal ADHD diagnosis 😮💨 The waiting lists are rather long... even when using the Right To Choose a mental health service provider.
Apologies for any typos.
#MentalHealth #depression #anxiety #burnout #neurodivergent #ADHD #AuDHD #NHS #NHSEngland #sertraline #SSRI #bupropion #NDRI #atomoxetine #sNRI #serotonin #noradrenaline #dopamine #RightToChoose #propranolol #diazepam #stimulants #methylphenidate
🚨Happy to share our lab's latest work! 🚨 #neuroscience #noradrenaline #stress
In 2016 I wrote a grant, asking a simple question: Stress triggers massive transcriptional changes, which of them are dependent on noradrenaline (NA) signaling?
Today, we have the answer, but boy was this a journey. A 🧵 👇
Is there anything the #LC can't do.?
“...activation of LC NEergic signaling during CFC memory encoding mediates engram early tagging in the mPFC and systems consolidation of remote memory“
Noradrenergic signaling mediates cortical early tagging and storage of remote memory | Nature Communications
https://www.nature.com/articles/s41467-022-35342-x
The locus coeruleus norepinephrine system plays a role in various cognitive functions. Here the authors show that in mice, locus coeruleus to medial prefrontal cortex norepinephrine release and β1-AR signaling during contextual fear conditioning are critical for remote memory storage.
With recent controversy and excitement in the #dopamine world, next comes this gem on the role of the #LC and #noradrenaline in prediction error-based learning
https://www.biorxiv.org/content/10.1101/2022.12.08.519670v1?s=08
Here, the authors showed that during decision-making, differential responses of #LC neurons match reward probabilities. Further, inhibition of the #LC disrupted learning based on #RPE
This validates another causal role for #LC heterogeneity /modularity that directly affects decision-making
A series of extremely cool #locuscoeruleus manuscripts have been put out there recently, and I wanna take the opportunity to highlight them in this🧵
Would love input from other #bluespot enthusiasts, since I'm definitely missing papers!
Maybe we can keep adding by replying, and eventually create an easily accessible list of publications that currently shape the #LC field
🔵
Kevin Karhan 
PLOS Biology
Dr Priya Sammani ( MBBS ,DFM )
LO Chou
SleepyCatten
Johannes Bohacek
Dilek Mercan
Danai Riga