Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

Howard G. Smith MD, AM on Instagram: "Obesity Cripples Anti-Bacterial Immunity Obesity due to consistent ingestion of a high-fat diet limits that ability of your white blood cells to effectively fight bacterial infections. Pediatric researchers at the University of Michigan studied this phenomenon in a mouse model and now report their findings in The Journal of Immunology. Obesity was induced with a sustained, 16 week, high fat diet. The bacteria-fighting lymphocytes, so-called neutrophils, generated by these obese mice produce diminished bactericidal secretions, are less capable of ingesting or phagocytosing these pathogens, and lack normal regenerative capabilities in comparison to those neutrophils found in control mice with normal weights. This study adds yet another reason for obese persons to cut out fats in their diets and normalize their body weights. Besides reducing the risk of heart attacks and alleviating the burdens their joints and backs must bear, they will repower their immune systems to protect them against serious and often life-threatening bacterial disease. https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf024/8081674 #obesity #fattydiet #bacteria #immunity #neutrophils #phagocytosis"

0 likes, 0 comments - drhowardsmithreports on April 2, 2025: "Obesity Cripples Anti-Bacterial Immunity Obesity due to consistent ingestion of a high-fat diet limits that ability of your white blood cells to effectively fight bacterial infections. Pediatric researchers at the University of Michigan studied this phenomenon in a mouse model and now report their findings in The Journal of Immunology. Obesity was induced with a sustained, 16 week, high fat diet. The bacteria-fighting lymphocytes, so-called neutrophils, generated by these obese mice produce diminished bactericidal secretions, are less capable of ingesting or phagocytosing these pathogens, and lack normal regenerative capabilities in comparison to those neutrophils found in control mice with normal weights. This study adds yet another reason for obese persons to cut out fats in their diets and normalize their body weights. Besides reducing the risk of heart attacks and alleviating the burdens their joints and backs must bear, they will repower their immune systems to protect them against serious and often life-threatening bacterial disease. https://academic.oup.com/jimmunol/advance-article/doi/10.1093/jimmun/vkaf024/8081674 #obesity #fattydiet #bacteria #immunity #neutrophils #phagocytosis".

Immune cells ‘bandage’ wounds with bacteria-trapping goo

Cells called neutrophils form gooey rings around sites where skin is punctured, study in mice shows.

Neutrophil extracellular traps - Wikipedia

Long COVID syndrome in children: neutrophilic granulocyte dysfunction and its correlation with disease severity - Pediatric Research

Many children suffer from lingering symptoms after COVID-19, known as long COVID syndrome (LCS), otherwise called Post COVID-19 Condition (PCC). Despite extensive research, the prevalence of symptoms, its impact on quality of life, and underlying mechanisms still need to be fully understood. As neutrophilic granulocytes play an essential role in COVID-19, and their prolonged disruption was found to cause immunological diseases, we hypothesized their ongoing disturbed functionality in LCS. We studied 129 children with LCS, 32 convalescent children (CG+), and 8 uninfected children (CG−). Online questionnaires and in-person examinations assessed symptoms, quality of life, and functioning (QoL-F). Effector functions of neutrophilic granulocytes obtained from the venous blood of 29 LCS and 17 CG+ children were also investigated. Persistent fatigue was the most common symptom in children with LCS, while both control groups complained about anxiety most frequently. LCS children experienced significantly more symptoms, impairing their QoL-F compared to CG+. Neutrophilic granulocyte dysfunction was found in LCS children, with decreased superoxide-producing activity and phagocytosis compared to CG+. The number of complaints of children with LCS correlated significantly with altered neutrophil effector functions. Neutrophil dysfunction in children with LCS may be part of the disease pathogenesis or a predisposing factor.

Integrin conformation-dependent neutrophil slowing obstructs the capillaries of the pre-metastatic lung in a model of breast cancer - preLights

Pre-metastatic neutrophilia and lung-metastatic breast cancer: a one-two punch to the lungs