In some #neurodegenerative diseases, TDP-43 is both lost from the nucleus & forms clumps in the cytoplasm. These two pathologies can be challenging to model but a study in @PLOSBiology presents a new system that captures both features. Paper: https://plos.io/4sxw0g9 Primer: https://plos.io/4bvWGrw

This brief highlights a biomarker-based approach that aligns with preventative and longitudinal care efforts in mental health. The work uses a blood-based indicator (p-tau217) to estimate the timing of symptom onset, offering potential to inform early planning, risk communication, and collaboration with families. For clinicians across psychotherapy, social work, and broader mental health practice, the emphasis on forecasting progression supports proactive case management and individualized care trajectories without venturing into clinical directives.

Article Title: Simple blood test can forecast Alzheimer’s years before memory loss

Link to Science Daily Mind-Brain News: https://www dot sciencedaily dot com/releases/2026/02/260222085203 dot htm

#Alzheimer prediction #biomarkers #mentalhealthcare #neurodegenerative #clinicalinformatics

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Microbial SCFAs as #epigenetic mediators: fine-tuning the gut-brain axis in #neurodegenerative disorders.

Short-chain fatty acids from gut microbes modulate brain epigenetics, offering neuroprotective effects & therapeutic potential for neurodegenerative disorders.

https://davidojcius.blogspot.com/2026/02/microbial-scfas-as-epigenetic-mediators.html #OpenAccess #microbiota #SCFA #microbiology

Hey #academicsky / #neurosky! If you're a stats- & bioinformatics-oriented #PhD looking for an adventure in #neuroscience focusing on #neurodegenerative disorders such as #parkinson 's disease, apply for this #postdoc position at our lab in Umeå—the friendliest most family-friendly town in #sweden 🤗

Postdoctoral position in the m...
Postdoctoral position in the molecular biology of Neurodegenerative diseases

We are seeking a highly motivated candidate who has recently completed, or is close to completing, a PhD and has training in statistics, data processing, bioinformatics, or a related discipline, to co

Chemical in #Roundup that causes brain damage found in common #cereals, new study finds

December 5, 2024 | Vivek Saxena

"Brief exposure to a weed killer found in breakfast cereals, oats, and orange juice has been shown to cause damage to the human body and brain.

"The weed killer, glyphosate (also known as Roundup), 'is the most widely used herbicide in the US,' according to the Center for Environmental Health.

" 'It is the most commonly used pesticide [#herbicide] in parks and is even found in foods that adults and kids love,' the center notes.

"Yet a new study conducted by Arizona State University researcher Ramon Velazquez and his team has found that active exposure to glyphosate 'can result in significant #BrainInflammation, and increase the risk of #neurodegenerative disease and #Alzheimer’s-like effects,' as reported by Arizona State University (#ASU).

" 'Our work contributes to the growing literature highlighting the brain’s vulnerability to glyphosate,' Velazquez said in a statement. 'Given the increasing incidence of #CognitiveDecline in the aging population, particularly in rural communities where exposure to glyphosate is more common due to large-scale #farming, there is an urgent need for more basic research on the effects of this herbicide.'

" 'My hope is that our work drives further investigation into the effects of glyphosate exposure, which may lead to a reexamination of its long-term safety and perhaps spark discussion about other prevalent toxins in our environment that may affect the brain,' additional study author Samantha Bartholomew added.

"The study involved testing both a high dose and low dose of glyphosate exposure on mice, with the lower dose being around the level that’s found in common foods like cereal and orange juice. While the high dosage dose caused issues, so did the lower dose.

" '[The] lower dose still led to harmful effects in the brains of mice, even after exposure ceased for months,' according to ASU. 'While reports show that most Americans are exposed to glyphosate daily, these results show that even a short period could potentially cause neurological damage.'

"A previous study commissioned by #MomsAcrossAmerica in 2017 found that one of the most popular #OrangeJuices in America, #Tropicana, also contains glyphosate.

" 'The discovery of glyphosate residue in orange juice is unacceptable, especially since a branch of the World Health Organization designated glyphosate a probable #carcinogen two years ago, back in the spring of 2015,' Moms Across America founder Zen Honeycutt said in a statement at the time.

" 'The EPA has had ample time to revoke the license of this chemical and restrict its use in our food and beverage crops. As confirmed by the American Academy of Pediatrics, our children (who frequently drink orange juice for breakfast) are especially vulnerable to pesticides and measures should be taken immediately to protect them,' she added.

"What remains to be seen is how the upcoming Trump Environmental Protection Agency will deal with this." [We know how that went!!! More #EPAFails!]

Read more:
https://www.bizpacreview.com/2024/12/05/chemical-in-roundup-that-causes-brain-damage-found-in-common-cereals-new-study-finds-1507592/

#EPAFail #Bayer #ToxicPesticides
#Monocrops #Monocrap #BigAg
#BigChem #Corruption #Poison #Crapitalism #CapitalismKills #RoundUpKills #USPol #WorldPol #Roundup #Glyphosate #BreakfastCereals #OrangeJuice

Chemical in Roundup that causes brain damage found in common cereals, new study finds

Brief exposure to a weed killer found in breakfast cereals, oats, and orange juice has been shown to cause damage to the human body and brain.

BizPac Review
First ALS Reversal Reported Using Brain Temperature Therapy

BTT Medical Institute last week reported the first documented case of total reversal of Amyotrophic Lateral Sclerosis (ALS) using Computerized Brain-Guided Intelligent Thermofebrile Therapy (CBIT²), a noninvasive treatment that modulates brain temperature in real time.

Ground News

When three bright minds from different disciplines come together, something exceptional can happen. 🌟 This is exactly what Prof. Patricia Hidalgo, Dr. Beatrix Santiago-Schübel, and Dr. Mercedes Alfonso-Prieto have achieved. 👩🔬

In an interdisciplinary project, they investigated how cells recognise and remove defective calcium channels – work that could prove significant not only for basic science, but also for future therapies for #neurodegenerative #diseases.

https://go.fzj.de/calcium-channels

Our life expectancy keeps rising – and as it does, age-related illnesses, including #neurodegenerative diseases such as #Alzheimer's and #Parkinson's become increasingly common.
#Neuroscience #MolecularBiology #sflorg
https://www.sflorg.com/2025/11/ns11212501.html
How the cheese-noodle principle could help counter Alzheimer's

The new findings could serve as a basis for developing novel therapies for such diseases.

A new strategy based on #stem cell therapy that could enhance neuronal regeneration and #neuroplasticity when this vital organ is damaged. The results reveal that the use of brain-derived neurotrophic factor (BDNF), combined with stem cell-based cell therapies, could help in the treatment of #neurodegenerative diseases or #brain injuries.
#MolecularScience #Neuroscience #sflorg
https://www.sflorg.com/2025/10/mols10142501.html
New advances to boost regeneration and plasticity of brain neurons

BDNF is a protein that is synthesized mainly in the brain and plays a key role in neuronal development

An international research team led by Université de Montréal medical professor Shady Rahayel has made a major breakthrough in predicting #neurodegenerative diseases.
#Neuroscience #sflorg
https://www.sflorg.com/2025/09/ns09252502.html
Does isolated REM sleep behavior disorder predict Parkinson’s disease or dementia?

it’s possible to distinguish early on who will develop which neurodegenerative disease—and when.