The #TREOCAPA trial is out, comparing paracetamol vs placebo for prophylactic tx of the PDA in infants <29w. More ducts closed but no diff in disease free survival…
More confusion on a higher level?!

https://pubmed.ncbi.nlm.nih.gov/41697673/

#NeoMastodon #NeoEBM

Prophylactic Treatment of Patent Ductus Arteriosus With Acetaminophen: A Randomized Clinical Trial - PubMed

ClinicalTrials.gov Identifier: NCT04459117.

PubMed
Great to see that Prof Gautham Suresh takes over as chair of EBNEO!
Lets hope Gautham and team starts to share #NeoEBM also in the #nicuverse !
The plan is also to register EBNEO as a nonprofit org in the US (and de-reg as a nonprofit org in Sweden), a good step forward as the organisation is mostly led by US academics now. Glad to have seen it grow, from the early roots within @99nicu and @karolinskainstitutet !
Do blood transfusions treat apnoea of prematurity?

There has for a long time been a thought that anemic babies with many apnoeas could benefit from a blood transfusion which would decrease their apnoeic spells. This idea has never been directly tes…

Neonatal Research
Propensity score matching, as explained in this great stat series by NEJM.
Silly context example (“how are ratings for maple syrups compare?”) but otherwise good to get how it works.
BTW, it’s a bad decision by NEJM to place this content behind their paywall. To paraphrase the old saying - Education wants to be free!
#NeoMastodon #NeoEBM
https://evidence.nejm.org/doi/full/10.1056/EVIDstat2500246
How Propensity Scores Work

This Stats, STAT! animated video explores the use of propensity scores — a method of controlling for observed confounders in non-randomized studies.

NEJM Evidence
Article of the Year - Evidence-Based Neonatology

Which Publication Will Be Crowned the 2024 EBNEO Impact Article of the Year? October 7, 2025 The community vote is back, and this time it is the final round. We extend our sincere thanks to everyone who participated in the first round of voting and helped us celebrate the research shaping neonatal care worldwide. After … Continue reading "Article of the Year"

Evidence-Based Neonatology

Which Publication Will Have the Most Impact on Neonatal Care?
Help Select the 2024 EBNEO Impact Article of the Year!

Click here to find the nominees and vote: https://ebneo.org/impact

#nicuverse #NeoMastodon #NeoEBM

Article of the Year - Evidence-Based Neonatology

Which Publication Will Be Crowned the 2024 EBNEO Impact Article of the Year? October 7, 2025 The community vote is back, and this time it is the final round. We extend our sincere thanks to everyone who participated in the first round of voting and helped us celebrate the research shaping neonatal care worldwide. After … Continue reading "Article of the Year"

Evidence-Based Neonatology
Important new study. 👉👉 In a very large population study South Korean researchers find no association between early life antibiotic exposure and overall risk of autoimmune disease in children. #NeoEBM #neosky journals.plos.org/plosmedicine...

Exposure to antibiotics during...
Exposure to antibiotics during pregnancy or early infancy and the risk of autoimmune disease in children: A nationwide cohort study in Korea

In a nationwide Korean cohort study, Ju-Young Shin and colleagues investigated whether there is an association between early life exposure to antibiotics and the development of autoimmune diseases.

Discover our latest issue on parenting interventions in the NICU – don't miss out!
https://onlinelibrary.wiley.com/toc/16512227/2025/114/4
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Very preterm infants with pulmonary hypertension - if the respond to iNO their survival chance seems better.
Relevant findings!
#NeoEBM #NeoMastodon
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2830084
Ida Lagerström - a raising star in perinatal epidemiology and clinical obstetrics!
She had her halftime-PhD seminar today, her thesis includes a very nice project (population-based register data etc) on term infants with Apgar
Score 0 at 10’, and their short and long term outcomes. Stay tuned until #jENS2025 in Belgrade!
(but hope to share paper1 here before the summer, manuscript to be submitted soon)
#NeoEBM #NeoMastodon