Faster, clearer, deeper 3D imaging

It’s hard to see deep into tissues – a time-consuming process that can produce blurred images. So, researchers at our Uni, UMG and Lubeck developed an innovative light sheet fluorescence microscopy platform. Now, more detailed scans of fine networks of nerves or blood vessels are possible: https://www.uni-goettingen.de/en/3240.html?id=8057

https://www.uni-goettingen.de/en/3240.html?id=8057

Research in #NatureBiotechnology: https://doi.org/10.1038/s41587-025-02882-8

#RapidHighResolutionImaging #MBExC #Microscopy

Ein Team unter Führung von Forscher:innen @Helmholtz_HIRI entwickelte eine innovative Methode zur Feinjustierung von genetischem Material, inspiriert von einem Abwehrmechanismus von Bakterien. Dabei werden gezielt chemische Markierungen an das Erbgut angefügt, wodurch sich neue Möglichkeiten der Genom-Editierung für Medizin, Landwirtschaft und Biotechnologie eröffnen. Die Methode wurde im Fachjournal #NatureBiotechnology vorgestellt. https://www.helmholtz-hzi.de/media-center/newsroom/news-detailseite/vom-abwehrkampf-der-bakterien-inspiriert/
Vom Abwehrkampf der Bakterien inspiriert

Forschende des Helmholtz-Instituts für RNA-basierte Infektionsforschung (HIRI) haben eine innovative Methode zur Feinjustierung genetischen Materials entwickelt.

New paper out! Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome | Nature Biotechnology

https://www.nature.com/articles/s41587-025-02810-w

#soilmicrobiome #antibiotics #Bioinformatics #nanopore #ont #OpenAccess #naturebiotechnology #naturebiotech

Bioactive molecules unearthed by terabase-scale long-read sequencing of a soil metagenome - Nature Biotechnology

Optimized long-read sequencing constructs megabase-scale genome assemblies from complex soil samples.

Nature

I rarely toot, but I had to take my keyboard here to react on an opinion in the Nature Biotechnology issue.

The community of the DAO. Nat Biotechnol 41, 1357 (2023). https://doi.org/10.1038/s41587-023-02005-1

Weren't all of us, except the worst grifter, agreeing that crypto-money was just a grift, solving basically no problem? DAOs are just an extension of crypto-money, trying to make the grift live a bit longer. I will not go over all the problem that goes into blockchains and deregulated markets, some people have done that way better than me, but DAOs are just a way to get new people to buy into it.
Worst here, it is trying to get people with good intentions, a curious mind, and a wish to help human progress to buy into something that is anything but that. It is honestly disgusting.

Even if it is in the opinion section of a sub-journal, I am pretty appalled seeing that kind of thing in a Nature journal. I really hope there will be some reaction against it. We don't need that crap invading the research space. Finding money is one of the worst parts of research, and I am all for trying to find new ways of raising funds. But a DAO ain't it. If you want to crowdfund your project (basically what is proposed here), there exist ways that are way better than a Ponzi scheme that ruins the environment. Don't buy into that crap.

#science #sciencefunding #nature #naturebiotechnology #opinion

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Excited to see our study "Predicting prime editing efficiency and product purity by deep learning" published in #NatureBiotechnology today! @schwanklab @krauthammerlab https://www.nature.com/articles/s41587-022-01613-7

Predicting prime editing efficiency and product purity by deep learning - Nature Biotechnology

The design of prime editing guide RNAs is optimized by deep learning.

Nature

A study with WOW-effect from #NatureBiotechnology (@nature, @Nature)! It's really new hope for composite plants makers!

A composite plant has a mix of roots (non-transgenic and #transgenic) and a non-transgenic shoot. I.e. those plant is a "grafted" non-transgenic shoot on a half-transgenic #root system.

🧬Heritable transgene-free #GenomeEditing in #plants by grafting of wild-type shoots to transgenic donor rootstock.🧬
#plantbiology #CRISPR

👉https://doi.org/10.1038/s41587-022-01585-8

https://twitter.com/Alex_Kiryushkin/status/1610717576308621312?t=HvGFYdA-rhw-rbUn36RayQ&s=19

#introduction After 13 years of near daily terror for posting something as innocent as a sunset or cat pic, I’m migrating here. My interests are #politics #naturebiotechnology #physics #modernarchitecture
The lysosomal degraders - Nature Biotechnology

Inspired by PROTACs, new degraders are emerging that harness endocytosis and autophagy to send a wide array of targets to the lysosome for destruction.

Nature
Many in vitro #CRISPR knock-in approaches use small molecule drugs to improve the efficiency of homology-directed repair, but these drugs may or may not be safe in vivo. In this paper from #NatureBiotechnology, the authors find that an FDA-approved therapy, fludarabine, can be used for a similar purpose. Still a long ways to go before any genetic knock-ins are routinely done in vivo, but making progress toward doing so safely: https://www.nature.com/articles/s41587-022-01240-2 #science #medicine #GeneEditing #AAV
Fludarabine increases nuclease-free AAV- and CRISPR/Cas9-mediated homologous recombination in mice - Nature Biotechnology

Fludarabine-induced DNA damage pathways enhance the in vivo efficiency of homologous recombination-based gene editing.

Nature