New paper just out:

*Effects of Constant and Time-Varying Colloidal Stability on Metal Oxide Nanoparticle Agglomeration: Insights from Kinetic Monte Carlo Simulations*

https://doi.org/10.1016/j.ces.2026.123814

The research presented in this paper was undertaken with funding from UK Research and Innovation (UKRI), grant number EP/X022218/1, as part of the UK Japan Civil Nuclear Energy Collaboration Phase 9.

#AcademicChatter #MonteCarlo #KMC #Nanoparticle #Nuclear

A stabilized #MERS-CoV #spike ferritin #nanoparticle #vaccine elicits robust and protective neutralizing #antibody responses, https://etidiohnew.blogspot.com/2026/02/a-stabilized-mers-cov-spike-ferritin.html
A stabilized #MERS-CoV #spike ferritin #nanoparticle #vaccine elicits robust and protective neutralizing #antibody responses

New nanoparticle mRNA vaccine may be cheaper and 100 times more powerful

Researchers at MIT have just developed a new lipid nanoparticle that super-enhances the effectiveness of the mRNA vaccine in mice to a hundred times its stand-alone effectiveness, thus offering massive savings by reducing required dosages while also reducing toxicity in the liver.

New Atlas
Ah, the classic "I-totally-read-the-article" moment: Where cutting-edge #nanoparticle #science meets the thrilling world of #HTTP #errors. 🚫🔬 Who knew #transgene #expression could be as elusive as finding a competent #support team? 🤷‍♂️📞
https://phys.org/news/2025-05-nanoparticle-cell-interface-enables-electromagnetic.html #team #science #humor #HackerNews #ngated
Nanoparticle-cell interface enables electromagnetic wireless programming of mammalian transgene expression

Recent technological advances are fueling the development of cutting-edge technologies that can monitor and control physiological processes with high precision. These include devices that could control the expression of genes within living organisms, without requiring invasive surgeries or procedures.

Phys.org

Now @ #DESY #UM25:

15th Workshop on X-Ray Nano-Imaging of Biological and Chemical Systems at PETRA III

“The workshop gives attention to x-ray #microscopy at various PETRA III beamlines with special emphasis on
applications in #biology and #chemistry. Several scientific (multimodal) #XRay #imaging highlights are presented
with focus on the scanning X-ray microscopy beamlines P06, P10 and P05.”

– Diamond-CRLs
– Multibeam #Ptychography
#Nanoparticle distribution
#Nanoscopy: #semiconductors

Researchers developed a faster and more precise method to study #nanoparticle #coatings using advanced microscopy. These methods uncover previously unseen surface patterns, helping scientists improve the performance of nanoparticles used in #DrugDelivery and #biosensing. Learn more: https://ilphotonics.com/finding-a-better-way-to-study-nanoparticle-coatings/

#Immunogenicity & #biodistribution of lipid #nanoparticle formulated self-amplifying #mRNA #vaccines against #H5 avian #influenza, npj Vaccines: https://www.nature.com/articles/s41541-024-00932-x

Cellular immune responses & #antigen-specific #IgA antibodies in #lungs were also observed. Comparison of sa-mRNA vaccines encoding secreted & membrane-anchored full-length HA revealed that anchoring of HA to the membrane significantly enhanced the antibody and cellular responses.

Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza - npj Vaccines

This study reports on the immunogenicity and biodistribution of H5 hemagglutinin (HA)-based self-amplifying (sa) mRNA vaccines in mice. Four sa-mRNA vaccines encoding either a secreted full-length HA, a secreted HA head domain, a secreted HA stalk domain, or a full-length membrane-anchored HA were investigated. All vaccines elicited an adaptive immune response. However, the full-length HA sa-RNA vaccines demonstrated superior performance compared to head and stalk domain vaccines. The antibody titers positively correlated with the vaccine dose. Cellular immune responses and antigen-specific IgA antibodies in the lungs were also observed. The comparison of the sa-mRNA vaccines encoding the secreted and membrane-anchored full-length HA revealed that anchoring of the HA to the membrane significantly enhanced the antibody and cellular responses. In addition to the injection site, the intramuscularly injected sa-mRNA-LNPs were also detected in the draining lymph nodes, spleen, and to a lesser extent, in the lung, kidney, liver, and heart.

Nature
Treatment with the #nanoparticle reduced #ovarian #tumor growth by more than 50% in human cells and animal models. Women diagnosed with ovarian #cancer may initially respond well to #chemotherapy, but the majority of them will develop resistance to treatment and die from the disease.
#Medical #sflorg
https://www.sflorg.com/2024/02/med02222402.html
Outsmarting chemo-resistant ovarian cancer

New approach with nanoparticle starves cells of cholesterol and reduces tumor growth by 50%

Lithium Battery for Electric Vehicles (EVs): Separators with coatings of Silica Nanoparticles enhance Safety  
Lithium-ion batteries for electric vehicles (EVs) face safety and stabilityissues due to overheating of separators, short circuits and reduced...........
#ElectricVehicles #EV #Lithium #LithiumBattery #Nanoparticle #Separators
Ume

https://www.scientificeuropean.co.uk/technology/lithium-battery-for-electric-vehicles-evs-separators-with-coatings-of-silica-nanoparticles-enhance-safety/

Lithium Battery for Electric Vehicles (EVs): Separators with coatings of Silica Nanoparticles enhance Safety  

Lithium-ion batteries for electric vehicles (EVs) face safety and stability issues due to overheating of separators, short circuits and reduced efficiency. With

Scientific European

I’m really shite at explaining things. I shovel info into my brain, note what repeated actions practically I have to take or what to avoid & leave the rest. Explaining is not my gift which is why I love others whose gift it is🖤

His response: (which came really quickly I might add🥰😍)

“No studies have been performed to measure nanoparticle-spike persistence in local or distal tissues”

And no studies have tested whether there’s a blue teapot orbiting Jupiter either (scientist snark) Point is that sure, this could be an issue. Sure, the nanos could also infest your brain, or it could this or that, but that doesn’t invalidate anything. This is FUD, (fear, uncertainty & doubt) - not invalid, but not a valid issue

“ ◦#Novavax expects a low potential for serious unwanted effects and toxicities in neonates, infants, and children” (they don’t know)
◦ “Novavax expects a low potential for serious unwanted effects and toxicities in pregnant women and fetuses” (they don’t know)
◦ “Novavax does not believe there are other special populations which would be more susceptible for serious unwanted effects and toxicities” (they don’t know)”

This is just dumb - who is this guy? Probably a MD, they think they understand science. Science doesn’t find Truth, it discovers truth. It will never be all encompassing. Short answer, we always will know less than can be known, so saying “they don’t know” is just asinine, of course they don’t! They can’t.

Addendum - studies cherry pick, you have to there’s never enough time or money. They studied the big issues, doubtful these are anything which is why they weren’t studied, and for darn sure getting COVID is worse (dumbass)

biodistribution of Novavax nanoparticle-spike has never been done and company “assumes” that it “mostly” stays in local lymph nodes because it should behave like a “conventional protein antigen” (it’s NOT, it’s a nanoparticle)

This looks like scare mongering, he doesn’t say anything but the word NANOPARTICLE is supposed to inspire fear, or something. A null statement.

OK

ALSO contains a saponin-based #MatrixM #adjuvant (40nm #nanoparticle, remarkably stable, held together by saponin-cholesterol interactions” (in rodents causes decreased body weight and red cell mass) – “may contribute to immunotoxicity”

This also is stupid - ask **** about how many times she’s heard **** or I say ANYTHING for certain - we don’t. We qualify everything. Built into techy types, we know nothing is known for 100% certainty - if you want that go join a religion

Yeah that’s probably enough too much to bother with, another technique FUD masters use is loooong, highly detailed posts that look smart and scientific, but it’s part of the advertising. Real scientists cut it short - that’s why there’s a précis/summary at the top. Get the idea in a paragraph and read the rest if you care

-End

Also his response to my Halloween wishes cracked me up🎃

Alas, must continue on that ball gown pattern I started yesterday (wrap apron dress but put anything poufy underneath instant ball gown) hence goblin trick 2 for tomorrow. These goblins & ghouls are so draining