The next big medical breakthrough may not be a complex drug—it could be a tiny molecule from a llama. 🤔 This is not science fiction; it’s real and happening now. Explore the world of nanobodies and discover how they’re transforming medicine. #Biotech #Pharma #DrugDiscovery #Nanobodies
http://learningbreeze.com/biology/nanobodies-medicine-therapies-vaccines/
A llama’s tiny antibodies may be the ultimate coronavirus defense — now and for pandemics to come. #Nanobodies #Coronavirus #Antiviral
https://geekoo.news/llama-antibodies-could-neutralize-all-sars-coronaviruses/
How do diverse synapses in the brain organize their nanoarchitecture to meet their different functional requirements? This study demonstrates the use of nanobodies combined with STED imaging to study the nanoarchitecture of thalamocortical and corticocortical synapses, revealing distinct principles of synaptic nano-organization in the brain.
#Nanobodies die erstaunliche, zufällige #entdeckung winziger Immunkörpermoleküle im Kamelblut revolutioniert die Behandlung schwerer Krankheiten zB Demenz ua. Als Krebspatient für mich extrem spannend 😎
#Structure defining of ultrapotent neutralizing #nanobodies against #MERS-CoV with novel epitopes on #receptor binding domain https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012438
These results not only character unprecedented epitopes for antibody recognition but also provide promising agents for prophylaxis and therapy of MERS-CoV infection.
Author summary MERS-CoV is one of the most prevalent zoonotic virus that has spread through 27 countries and infected more than 2,605 people since its first outbreak in Saudi Arabia in 2012. The high fatality rate and its persistent wide spread infectiousness in animal reservoirs have generated tremendous global public health concern. However, no licensed therapeutic agents or vaccines against MERS-CoV are currently available. To address the risk of MERS-CoV and its variants re-emergence, we developed four highly effective Nbs from alpaca and solved two crystal complexes of Nb9 and Nb14 with RBD. Remarkably, the neutralizing activity of Nb14 represents the highest of MERS-CoV antibodies reported to date. The novel epitopes of Nb14 and Nb9 locate outside the RBD and hDPP4 interface, and the unique different epitopes and mechanisms of Nb14 and Nb9 provide a better neutralizing for synergistically against MERS-CoV infection. Our findings provide insights into the cryptic epitopes on RBD and the development of antibodies against MERS-CoV infection.
17-JUL-2024
#Llama #nanobodies: A breakthrough in building HIV immunity
Biology researchers at Georgia State have developed a new antibody therapy that can neutralize a wide variety of #HIV-1 strains. They found success in an unlikely source — llamas.
It's 24 years since I wrote my first articles about camel and llama #antibodies, so the PR people could tone down the "unlikely" a little bit.
https://www.eurekalert.org/news-releases/1051719 #science #nanoworld
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Could the blood of camel species help save us from serious diseases? | DW Documentary
What’s known as #nanobodies from the blood of #camels are at the heart of a #medical revolution. Due to their special properties, these nanobodies can be used in a variety of ways, whether in the fight against #infectious diseases, in #cancer therapy or in the diagnosis of #Alzheimer's disease.
Small #antibodies with a big impact: camel blood contains #immunological superpowers. It all began in the 1990s with a chance #discovery at the Free #University of #Brussels: students used #dromedary blood in an experiment and came across previously unknown antibodies. The university #scientists discovered that these antibodies are present in all camel species. And, they have amazing properties. Small fragments can separate from the base of the antibody -- without causing any damage and while retaining their full binding capacity.
This was the discovery of the nanobody: a tiny, extremely robust #molecule which, due to its small size, can also penetrate areas too small to be targeted by complete antibodies. The nanobody, however, can attach itself with extremely high precision to pathogenic antigens.
This discovery triggered a wave of innovations and shook up the big #pharmaceutical companies. In 2018, the first drug based on nanobodies went on the market, designed to combat an autoimmune #blood clotting disorder. Numerous potential applications were developed within a very short space of time. Whether in the fight against cancer, in Alzheimer's diagnostics or to kill #pathogenic #bacteria - the success of camel antibodies has been so resounding that many #medical research centers now have their own herds of llamas or alpacas.
But why do members of the camel family in particular have such immunological superpowers? With the help of camel experts and microbiologists, the documentary sheds light on the surprising abilities of camels and the medical revolution of nanobodies.
MUDASSAR SALEEM
Geekoo
PLOS Biology
nico kruppe
Giuseppe Michieli
michael
Mastodon Trends South Africa
AfricaUnion