Stephan HackerDec 4, 2024
#NWOCHAINS2024 comes to an end with an inspiring plenary lecture by Andrea Rentmeister. She talked about her group's exciting work on making RNAs with new functions. Interesting insights into chemoenzymatic benzylation of the cap as well as making translation light-controlled. https://www.nature.com/articles/s41557-022-00972-7
Photocaged 5′ cap analogues for optical control of mRNA translation in cells - Nature Chemistry

Analogues of mRNA 5′ caps containing a photo-cleavable group have now been developed. These so-called FlashCaps can be used for routine in vitro transcription to make long mRNAs containing a cap. In cells, the capped mRNAs are translationally muted; however, upon irradiation by light, the photo-cleavable group is removed without leaving any remaining modification and mRNA is then translated into the corresponding protein.

Nature
Stephan HackerDec 4, 2024
#NWOCHAINS2024 comes to an end with an inspiring plenary lecture by Andrea Rentmeister. She talked about her group's exciting work on making RNAs with new functions. Interesting insights into benzylation of the cap as well as making translation light-controlled. www.nature.com/articles/s41...
Stephan HackerDec 4, 2024
Great talk by @p_vanderwel at #NWOCHAINS2024. He talked about his group's work on understanding the molecular structures of fibrils of mutant huntingtin protein occurring in Huntington’s disease using a combination of solid-state NMR, ER and simulation. https://www.biorxiv.org/content/10.1101/2023.07.21.549993v2
Stephan HackerDec 4, 2024
Great talk by @pcavanderwel.bsky.social at #NWOCHAINS2024. He talked about his group's work on understanding the molecular structures of fibrils of mutant huntingtin protein occurring in Huntington’s disease using a combination of solid-state NMR, ER and simulation. www.biorxiv.org/content/10.1...
Stephan HackerDec 4, 2024
The poster sessions are a highlight of #NWOCHAINS2024 but it is hard to get to all of them. The poster pitches were a great way to get a quick overview of the diverse topics including the research by Sean McKenna of @LED3hub on using "Active Learning for CCR2 inhibitor discovery"
Stephan HackerDec 4, 2024
The poster sessions are a highlight of #NWOCHAINS2024 but it is hard to get to all of them. The poster pitches were great to get a quick overview of the diverse topics including the research by @seanmckenna.bsky.social of @led3hub.bsky.social on using "Active Learning for CCR2 inhibitor discovery"
Egon Willigh☮gen 🟥Dec 4, 2024
the Dutch #chemistry community is attending #NWOCHAINS2024 this week. I cannot make it this year, but will be there next year. Have fun all, and keep the coverage on social media flowing! thx @stephanhacker2.bsky.social
Stephan HackerDec 4, 2024
Excited to see Julia Pols presenting their research in our group at #NWOCHAINS2024. They did a great job in giving a clear presentation on their PhD project on identifying new ligandable cysteines as antibacterial targets against MRSA. #proudPI #ChemBio #Antibiotics
Stephan HackerDec 4, 2024
Excited to see Julia Pols presenting their research in our group at #NWOCHAINS2024. They did a great job in giving a clear presentation on their PhD project on identifying new ligandable cysteines as antibacterial targets against MRSA. #proudPI #ChemBio #Antibiotics
Stephan HackerDec 4, 2024
Amazing talk by Marthe Walvoort at #NWOCHAINS2024 in front of a full house. She talked about her group's exciting work on the isolation of polysaccharides of bacteria as well as the synthesis of probes to better understand their role in health and disease. https://pubs.rsc.org/en/content/articlehtml/2023/cb/d3cb00110e