Our #NEIfunded study led by Farhad Farjood, Nathan Boles & Jeffrey Stern reveals heterogeneity of retinal pigment epithelium cells in the human eye using #scRNA-seq & proteomics. We describe unique spatial patterns that suggest functional differences for RPE subpopulations in the eye.

- with S. Nandakumar, T. Bertucci, T. Kiehl, S. Lotz, Yue Wang, J. Black, S. Sai, J. Kozak, B. Arduini and S. Temple

This work was supported by the NIH & Luxa Biotech.

Full text | https://zurl.co/4hwI6

We are developing new methods to reverse vision loss due to #MacularDegeneration (dry AMD). Our unique approach uses adult stem cells to replace RPE cells that are lost in dry AMD. This RPE #stemcell therapy is being studied in our ongoing #NEIfunded #ClinicalTrial at the U-Michigan Kellogg Eye Center, led by Dr. Rajesh Rao and sponsored by Luxa Biotechnology.

Trial Info | https://zurl.co/B8Ja
Luxa | https://zurl.co/R2Ps

📷 Kate Tubbesing, Penny Rocchio, Brigitte Arduini (NSCI)

An important aspect of treating vision impairment is understanding the biology of eye cell types. Part of our #NEIfunded research program seeks to define attributes of retinal pigment epithelium (RPE) cells, which are affected in #MacularDegeneration.
#LowVisionAwarenessMonth

Journal of Experimental Medicine
Farjood, et al. | https://zurl.co/wFYe