Mastodawn

#SARS-CoV-2 Error Catastrophe Under #Molnupiravir: #Mutagenic Enhancement Enables Viral #Persistence with Impaired Fitness, https://etidiohnew.blogspot.com/2026/02/sars-cov-2-error-catastrophe-under.html

#SARS-CoV-2 Error Catastrophe Under #Molnupiravir: #Mutagenic Enhancement Enables Viral #Persistence with Impaired Fitness

Giuseppe Michieli Mar 15, 2024

#Genetic #consequences of effective and suboptimal dosing with #mutagenic #drugs in a #hamster model of #SARS-CoV-2 infection, Virus Evol.: https://doi.org/10.1093/ve/veae001

-- Our study suggests that where onward transmission occurs, a short period of treatment with mutagenic drugs may be sufficient to generate a significant increase in the number of viral #variants transmitted.

Genetic consequences of effective and suboptimal dosing with mutagenic drugs in a hamster model of SARS-CoV-2 infection

Abstract. Mutagenic antiviral drugs have shown promise against multiple viruses, but concerns have been raised about whether their use might promote the emergen

OUP Academic