mechanochemistry🚨 NEW PAPER 🚨
Vishakha and colleagues in the Cross group show that ATPγS causes single kinesin molecules to pause under load in an Await-Isomerisation (AI) state that leaks hand-over-hand backsteps.
"ATPγS substantially defeats the biasing mechanism for kinesin steps”
ATPγS substantially defeats the biasing mechanism for kinesin steps - Nature Communications
ATPγS, a slowly-hydrolysed ATP analogue, causes kinesin to take extra backsteps under load. Here, the authors examine single-molecule mechanics and propose a state in which forward steps and coupled ATP hydrolysis are turned off, but unsteered steps are allowed.
Curt Johnson - Indie Genius
Deadline
Aaron Fernandes
No Soy Original