LeszekApr 11, 2025
beloved #Mettl3 is involved in DNA repair by placing #m6A in #DNA
#modifications
https://elifesciences.org/articles/101626
N6-methyladenosine in DNA promotes genome stability

Single-cell imaging and mass spectrometry data reveal adenosine in the DNA of mammalian cells can be methylated by METTL3 to form N6-methyladenosine in response to DNA damage.

eLife
PLOS BiologyMar 8, 2023
Loss of #METTL3, and the resulting changes in m6A modifications, leads to enhanced #brain infiltration of monocyte-derived #macrophages in a mouse model of #AlzheimersDisease, promoting Aβ clearance and improving pathology & cognitive decline #PLOSBiology https://plos.io/3F1ClcQ
Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer’s disease pathology in mice

This study reveals that loss of METTL3, and the corresponding changes in m6A modifications, leads to enhanced brain infiltration of monocyte-derived macrophages in a mouse model of Alzheimer’s Disease, promoting Aβ clearance and ameliorating pathology and cognitive decline.

PLOS BiologyMar 8, 2023
Loss of #METTL3, and the resulting changes in m6A modifications, leads to enhanced #brain infiltration of monocyte-derived #macrophages in a mouse model of #AlzheimersDisease, promoting Aβ clearance and improving pathology & cognitive decline #PLOSBiology https://plos.io/3F1ClcQ
Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer’s disease pathology in mice

This study reveals that loss of METTL3, and the corresponding changes in m6A modifications, leads to enhanced brain infiltration of monocyte-derived macrophages in a mouse model of Alzheimer’s Disease, promoting Aβ clearance and ameliorating pathology and cognitive decline.

PLOS BiologyMar 8, 2023
Loss of #METTL3, and the resulting changes in m6A modifications, leads to enhanced #brain infiltration of monocyte-derived #macrophages in a mouse model of #AlzheimersDisease, promoting Aβ clearance and improving pathology & cognitive decline #PLOSBiology https://plos.io/3F1ClcQ
Loss of the m6A methyltransferase METTL3 in monocyte-derived macrophages ameliorates Alzheimer’s disease pathology in mice

This study reveals that loss of METTL3, and the corresponding changes in m6A modifications, leads to enhanced brain infiltration of monocyte-derived macrophages in a mouse model of Alzheimer’s Disease, promoting Aβ clearance and ameliorating pathology and cognitive decline.