🧩 What if the diverse functions of a single protein all trace back to one structural superfamily?

🔗 Evolutionary and structural bioinformatics identifies GPR89 as a conserved member of the LIMR protein superfamily. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.003

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #ComputationalBiology #MolecularEvolution #ProteinScience #Genomics #Proteomics #AlphaFold #MembraneProteins #Genetics #Bioinformatics

🔬 Could a tiny imbalance in ATP binding be the key to drug resistance in cancer?

🔗 Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, A computational study. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.064

📚 CSBJ: https://www.csbj.org/

#DrugResistance #MolecularDynamics #StructuralBiology #MembraneProteins #CancerResearch #Pharmacology #DrugDiscovery #ChemotherapyResistance #ProteinDynamics #Pgp #ABCB1 #Biophysics

Exploring ML + MD for membrane proteins: moving beyond manual inspection to detect events, change-points, and metastable states in long trajectories. Faster clustering, better patterns, fewer blind spots. Anyone pairing k-means with HELM or similar for refinement? 🤔

#MolecularDynamics #MachineLearning #Bioinformatics #MembraneProteins

https://is.gd/5Ycb2P

Postdoctoral Associate in Membrane Protein Structural Biology
Vecchio Lab at University at Buffalo

#postdoc in vecchio lab at university at buffalo department of #structuralbiology studying #membraneprotein #structureandfunction

See the full job description on jobRxiv: https://jobrxiv.org/job/university-at-buffalo-27778-postdoctoral-associate/

#biophysics #cryoEM #membraneproteins #proteinproteininter...
https://jobrxiv.org/job/university-at-buffalo-27778-postdoctoral-associate/?fsp_sid=2412

Postdoctoral Associate in Membrane Protein Structural Biology
Vecchio Lab at University at Buffalo

#postdoc in vecchio lab at university at buffalo department of #structuralbiology studying #membraneprotein #structureandfunction

See the full job description on jobRxiv: https://jobrxiv.org/job/university-at-buffalo-27778-postdoctoral-associate/

#biophysics #cryoEM #membraneproteins #proteinproteininter...
https://jobrxiv.org/job/university-at-buffalo-27778-postdoctoral-associate/?fsp_sid=1950

📝 Call for Papers: Special Issue on "Mechanistic insights into membrane protein dynamics and allostery: implications in drug discovery"

🔗Link to the 'Call for Papers': https://www.csbj.org/allostery

📊 Guest Editor:

🌟Prithviraj Nandigrami, Albert Einstein College of Medicine, USA

#membraneproteins #proteindynamics #proteinstructure #drugdiscovery #transmembranesignaling #molecularsimulation #therapeuticmolecules

Join #EMBOPEPC to learn how to troubleshoot in the wet lab during solubilisation and reconstitution, and how to conduct experiments at the beamlines and during early stages of cryoEM screening. 🔎⚡️

✍️ Apply by 17 June
🗓️ 9 – 16 September
📍 EMBL Hamburg
➡️ https://s.embl.org/pep24-01

#membraneproteins #structuralbiology #cryoem #saxs #macromolecularcrystallography #crystallography #biophysicalcharacterisation #cellbiology #spectrometry #enzymaticreactions #proteinmodelling

Postdoc - Membrane Protein Transport into Cilia

University of Oxford

Exciting opportunity to join the Roberts group @Dunn_School to study how #membraneproteins are transported into #cilia using #cryoEM

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-oxford-27778-postdoc-membrane-protein-transport-into-cilia/?feed_id=59857

#ScienceJobs #hiring #res...
https://jobrxiv.org/job/university-of-oxford-27778-postdoc-membrane-protein-transport-into-cilia/?feed_id=59857