🧬 Can salt levels change how cell-penetrating peptides behave at membranes?

🔗 Molecular dynamics simulations unveil the aggregation patterns and salting out of polyarginines at zwitterionic POPC bilayers in solutions of various ionic strengths. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.004

📚 CSBJ: https://www.csbj.org/

#MolecularDynamics #PeptideAggregation #MembraneProtein #Biophysics #StructuralBiology #ProteinFolding #MembraneBiology

🧫 What secret molecular choreograph helps bacteria stay resilient against antibiotics and detergents?

🔗 Coordinated subdomain movements of MlaC regulate ligand binding and transport. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.031

📚 CSBJ: https://www.csbj.org/

#Microbiology #AntibioticResistance #MembraneBiology #StructuralBiology #ComputationalChemistry #MolecularDynamics #ComputationalBiology #Biophysics #ProteinStructure #DrugDiscovery #MolecularDocking

🦠 What makes antimicrobial peptides so selective against bacteria and cancer cells, while leaving healthy cells intact?

🔗 Unlocking the specificity of antimicrobial peptide interactions for membrane-targeted therapies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.04.022

📚 CSBJ Nanoscience & Advanced Materials: https://csbj.org/nano

#AntimicrobialPeptides #DrugDiscovery #MolecularDynamics #Biophysics #MembraneBiology #Bioinformatics #PeptideTherapeutics