"The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex", Bodor et al. 2025 (Nuno da Costa's lab)
https://www.nature.com/articles/s41593-025-02004-2

#neuroscience #MICrONs #connectomics #CerebralCortex

The synaptic architecture of layer 5 thick tufted excitatory neurons in mouse visual cortex - Nature Neuroscience

This study maps the connections of layer 5 pyramidal neurons in the mouse cortex, revealing distinct local and intercortical wiring patterns, and provides an open framework for exploring the connectivity of cell types.

Nature

Scientists have created the most detailed wiring diagram of the brain ever, thanks to IARPA’s MICrONS program. They mapped over 200,000 cells and 500 million synapses in a mouse’s visual cortex, linking structure and function at an unprecedented scale. This breakthrough could revolutionize our understanding of cognition, consciousness, and brain disorders.

@goodnews

#Neuroscience #BrainMapping #MICrONS #IARPA #Consciousness #GoodNews
https://thedebrief.org/iarpa-research-achieves-the-impossible-in-new-breakthrough-revealing-the-brains-biggest-mysteries/

IARPA Research Achieves the Impossible in New Breakthrough Revealing the Brain's Biggest Mysteries

Science, Tech and Defense for the Rebelliously Curious.

The Debrief

Scientists achieve a historic milestone by creating the most comprehensive wiring diagram and functional map of a mammalian brain, offering unprecedented insights into neural connectivity. #Neuroscience #BrainMapping #MICrONS

https://geekoo.news/mapping-the-mind-unveiling-the-brains-most-detailed-wiring-diagram/

Mapping the Mind: Unveiling the Brain's Most Detailed Wiring Diagram | Geekoo

Scientists achieve a historic milestone by creating the most comprehensive wiring diagram and functional map of a mammalian brain, offering unprecedented insights into neural connectivity.

Geekoo

Wie funktioniert das #Gehirn? Mit dem bisher größten Schaltplan und der größten Funktionskarte eines Säugetiergehirns ist ein weltweites Team mit Beteiligung unserer Uni der Antwort näher gekommen.

Das Team kombinierte Live-Aufnahmen von Gehirnbildern mit hochauflösender #Mikroskopie und #KI, um nie zuvor gesehene Einblicke in die Funktion und Organisation des Sehsystems des Gehirns zu gewinnen: https://www.uni-goettingen.de/de/3240.html?id=7776

Übersicht über die Paper in #nature: https://www.nature.com/immersive/d42859-025-00001-w/index.html

#MICrONS

Presseinformationen - Georg-August-Universität Göttingen

Webseiten der Georg-August-Universität Göttingen

Georg-August Universität Göttingen
Inhibitory specificity from a connectomic census of mouse visual cortex - Nature

Using volumetric electron microscopy, the authors map and analyze the structure of cortical inhibition with synaptic resolution across a column of visual cortex.

Nature

Scientists map the half-billion connections that allow mice to see https://www.princeton.edu/news/2025/04/09/first-time-scientists-map-half-billion-connections-allow-mice-see #MICrONS project

The MICrONS Project https://www.nature.com/immersive/d42859-025-00001-w/index.html "An unprecedented dataset of high resolution anatomical images of individual cells in mouse visual cortex, mapped on to their responses. This integrated view of function and structure lays a foundation for discovering the computational bases of cortical circuits."

Scientists map the half-billion connections that allow mice to see

The stunning research is supercharging our understanding of human brain disorders and advancing U.S. national interests in artificial intelligence.

Princeton University
They said it couldn't be done ... but neuroscientists have successfully mapped all the cells in a cubic millimeter of #brain tissue, and have traced how the neurons fire. Find out more about the $100 million #MICrONS project and the role that Seattle's #AllenInstitute is playing. https://www.geekwire.com/2025/brain-microns-wiring-diagram-connections/ #Science #Neuroscience
Since I have recently rediscovered traditional aquarelle painting for myself, here is another small work (and a few colour and composing tests).

It's a beach inspired by a photo I found on unsplash of Luskentyre Beach on the Isles of Harris – man, I'd love to go there sometime, it looks absolutely stunning. (My painting doesn't do it justice.)

#traditional #aquarelle #painting #microns #watercolor #beach
Results: In this study of the #MICrONS 🐭👁️-cortex 3D #ElectronMicroscopy dataset, I show how the shape of #Contractile #MuralCells transition from #PenetratingArteriole to #PrecapillarySphincter to #Capillaries. Vascular lumen = blue, mural cells = various colors (5/15)
I alternated waterslides and cherry blossoms for a while this spring, with blank pages in between. Now I'm working on making all the slides bloom with the magic of tracing and imagination. #moleskine #microns #drawing