PLOS BiologyThis study shows that #RNAsplicing is widely dysregulated when #FMRP is lost; this involves multiple splicing factors, including MBNL1. In FMRP-depleted cells, Mbnl1 RNA is misspliced, mislocalizing #MBNL1, and in turn messing up further RNAs #PLOSBiology https://plos.io/3R6E9GN
FMRP deficiency leads to multifactorial dysregulation of splicing and mislocalization of MBNL1 to the cytoplasm
This study shows that RNA splicing is widely dysregulated in FMRP-deficient mouse tissues and cells and involves multiple splicing factors, including MBNL1. In FMRP-depleted cells, Mbnl1 RNA is mis-spliced, resulting in improper cytoplasmic localization of MBNL1, which in turn causes impairment of further RNAs.