Biology OpenJan 24, 2023

Siti Nur Sarah Morris and colleagues carry out a genome-wide #CRISPR screen and reveal a role for TMEM30A-regulated #membrane assembly in determining #cancer cell sensitivity to ceramide-induced cell death:

https://journals.biologists.com/bio/article/11/12/bio059695/286108/A-genome-wide-CRISPR-screen-implicates-plasma

#Screen #Lipids #Sphingolipid #Lipotoxicity #Science #BiologyOpen #Biology #Science #AcademicMastodon

genome-wide CRISPR screen implicates plasma membrane asymmetry in exogenous C6-ceramide toxicity

Summary: A genome-wide CRISPR screen reveals a role for TMEM30A-regulated membrane asymmetry in governing cancer cell sensitivity to ceramide-induced cell death.

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