Researchers write “A sample of 11,441 patients was analyzed, At-home, telehealth-supported ketamine administration was largely safe, well-tolerated, and associated with improvement in patients with depression. Strategies for combining psychedelic-oriented therapies with rigorous telehealth models, as explored here, may uniquely address barriers to mental health treatment.” https://psychedelicmentalhealth.net/psychedelic-therapy-cognitive-behavioral-therapy-ketamine-context-competencies/ #ketamine #mentalhealth #psychedelics #ketaminetherapy #harmreduction #psychedelicinstituteproject
Psychedelic Cognitive Behavioral Therapy: On Ketamine, Context, and Competencies in "Assisted-Psychotherapy”

There are many tools to help a psychotherapist help clients learn to speak the language of cognitive behavioral therapy, especially tools which may help facilitate therapeutic alliance, including, but not limited to telehealth.

Psychedelic Institute - Psychedelics in Mental Health
Rational Ketamine Practice and the Current Ketamine Discourse

(Drafts ongoing)

Psychedelic Institute - Psychedelics in Mental Health
Blood biomarker changes and relationships after low dose oral ketamine treatment for post-traumatic stress disorder (PTSD) (Quigley, et al, 2026) https://link.springer.com/article/10.1007/s00213-026-07043-6 “#ketamine effects may rely on a reciprocal interaction between BDNF and VEGF-A, offering potential insights into a biological mechanism underpinning #ptsd symptom reduction.” (Also from this paper- #ketamine has been studied for ptsd for 20 years!) #psychedelic #ketaminetherapy #psychedelics #mentalhealth
Blood biomarker changes and relationships after low dose oral ketamine treatment for post-traumatic stress disorder (PTSD) - Psychopharmacology

Ketamine has been investigated as a treatment alternative for PTSD for the last 20 years, yet there have been limited reports of biological changes or biom

SpringerLink
Decoding the molecular network communication mechanism of ketamine’s antidepressant effects (Li, et al, 2026) https://link.springer.com/article/10.1007/s00213-026-07028-5 #ketamine #brains #mentalhealth #ketaminetherapy #depression #psychedelics

#til one if the first #ketamine studies for #mentalhealth was in 1973 out of #iran “The Use of Ketamine in Psychiatry” by
E. Khorramzadeh M.D, A.O. Lotfy M.D.
Assistant Professor, Dept. of Psychiatry, Pahlavi University School of Medicine, Shiraz, Iran
Professor, Dept. of Anesthesiology, Pahlavi University School of Medicine, Shiraz, Iran #psychedelics #ketaminetherapy #psychedelicresearch #nowar

https://www.sciencedirect.com/science/article/pii/S0033318273713062?via%3Dihub

Psychedelic Institute (@PlanetMedicine) on Flipboard

Visit us at https://psychedelicmentalhealth.net y https://institutopsicodelico.org

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Brain scans reveal how ketamine quickly lifts severe depression
Scientists have finally visualized how ketamine rewires key brain receptors to rapidly relieve treatment-resistant depression. (2026) https://www.sciencedaily.com/releases/2026/03/260307213234.htm #depression #brains #ketamine #mentalhealth #ketaminetherapy #psychedelics
Brain scans reveal how ketamine quickly lifts severe depression

A new brain-imaging study has revealed how ketamine produces its fast antidepressant effects in people with treatment-resistant depression. Researchers tracked changes in a critical brain receptor that helps neurons communicate and found that ketamine reshapes its activity in specific brain regions tied to mood and reward. These shifts strongly matched improvements in patients’ symptoms. The findings could help scientists develop better ways to predict who will benefit from ketamine therapy.

ScienceDaily
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health
Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth. (DeMarco, 2024) https://psychedelicmentalhealth.net/ketamine-oral-sublingual-research/ #ketamine #ketaminetherapy #ketamineassistedpsychotherapy
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health

Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth.

Psychedelic Institute - Psychedelics in Mental Health
Effect of Ketamine on Reward Processing in Depressive Disorders: A Systematic Review of
Neuroimaging Studies (Faisal, et al, 2026) "This systematic review found that ketamine administration is associated with neurofunctional
changes in reward-related circuitry in adults with MDD/TRD, most consistently involving the
ventral striatum/NAc and connected ACC–prefrontal networks. “ https://www.cambridge.org/core/journals/cns-spectrums/article/effect-of-ketamine-on-reward-processing-in-depressive-disorders-a-systematic-review-of-neuroimaging-studies/088C187F43710A29CE43B72CB5F74006 #ketamine #depression #mentalhealth #brains #neuroscience #ketaminetherapy
Effect of Ketamine on Reward Processing in Depressive Disorders: A Systematic Review of Neuroimaging Studies | CNS Spectrums | Cambridge Core

Effect of Ketamine on Reward Processing in Depressive Disorders: A Systematic Review of Neuroimaging Studies

Cambridge Core
PAINscape-Exploring patient experiences with ketamine for chronic neuropathic pain: A qualitative study (Parakh, et al, 2026) All participants described decreased pain intensity and increased functionality after receiving ketamine treatment. Barriers to ketamine treatment included fragmented health systems and long wait times, along with a struggle for pain validation by health care providers. https://pubmed.ncbi.nlm.nih.gov/41798319/ #ketamine #pain #painmanagement #chronicpain #psychedelics #ketaminetherapy
PAINscape-Exploring patient experiences with ketamine for chronic neuropathic pain: A qualitative study - PubMed

Although pain experiences differed among participants, all participants reported decreased pain with ketamine infusions. Addressing the stigma associated with ketamine infusions, further research around augmenting durability of ketamine, and providing a safe treatment environment can all improve ket …

PubMed