
Spotlight: The effects of low-dose ketamine and (2R,6R)-Hydroxynorketamine on affective behaviors associated with protracted oxycodone withdrawal (Lehane, et al, 2025)
"These findings demonstrate the therapeutic potential of (2R,6R)-HNK and ketamine in alleviating affective symptoms of oxycodone withdrawal. "
Psychedelic Institute of Mental Health & Family Therapy
Spotlight: Comparative Effects of Repeated Ketamine Infusion Versus Intranasal Esketamine in Patients With Treatment-Resistant Depression: A Retrospective Chart Review (Meisner, et al, 2025)
"In this naturalistic sample of patients with similarly severe TRD treated in a ketamine subspecialty service over a 4–5-week induction period, treatment with IV racemic ketamine was associated with a more rapid response and greater overall efficacy than treatment with IN esketamine."
Psychedelic Institute of Mental Health & Family Therapy
Brain study challenges long-held views about Parkinson's movement disorders
Latest Parkinson's research and breakthroughs
CureDigest
Is Ketamine Neurotoxic? - Desmolysium
I discuss ketamine, and my person experience with it, in more detail here. At recreational doses, ketamine is addictive, destroys the bladder, and is toxic to the central nervous system. Microscopic lesions (including but not limited to so-called “Olney’s lesions”) in both grey and white matter are evident already after three months of high-dose ketamine […]
Desmolysium