https://psychedelicmentalhealth.net/intravenous-ketamine-intranasal-esketamine-depression-research-2025/ Spotlight: Intravenous Ketamine Followed by Intranasal Esketamine in 2 Subsequent Treatment-resistant Depressive Episodes: Insights From a Case Series (Carminati, et al, 2025)
"Findings from this case series suggest that both
#ketamine and esketamine are associated with significant reductions in depressive symptoms in TRD. We observed a generally better response to ketamine than to esketamine."
#ketamineassistedtherapy #ketaminetherapy #depression #mentalhealth 
Spotlight: Intravenous Ketamine Followed by Intranasal Esketamine in 2 Subsequent Treatment-resistant Depressive Episodes: Insights From a Case Series (Carminati, et al, 2025)
"Findings from this case series suggest that both ketamine and esketamine are associated with significant reductions in depressive symptoms in TRD. We observed a generally better response to ketamine than to esketamine."
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health
Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth.
https://psychedelicmentalhealth.net/spotlight-a-retrospective-analysis-of-ketamine-intravenous-therapy-for-post-traumatic-stress-disorder-in-real-world-care-settings-mcinnes-et-al-2025/ Spotlight: A retrospective analysis of ketamine intravenous therapy for post-traumatic stress disorder in real-world care settings (McInnes, et al, 2025)
"In a large real-world sample of 8,136 PTSD patients (87 % with comorbid depression), Ketamine Intravenous Therapy (KIT) significantly reduced PTSD and depression symptoms." #ketamine #ketaminetherapy #ivketamine #ketamineassistedtherapy #mentalhealth #ptsd #depression #psychedelics #psychedelic
Spotlight: A retrospective analysis of ketamine intravenous therapy for post-traumatic stress disorder in real-world care settings (McInnes, et al, 2025)
"In a large real-world sample of 8,136 PTSD patients (87 % with comorbid depression), Ketamine Intravenous Therapy (KIT) significantly reduced PTSD and depression symptoms."
Sublingual & Oral Ketamine Research: Efficacy, Dosage, and Treatment for Mental Health
Ongoing review of the literature related to safety and efficacy of ketamine and esketamine by mouth.
SMART Recovery® Podcast: Psychedelic Assisted Therapy: Research and Practice
Dr. Michael DeMarco is a licensed mental health and family therapist and has pursued additional training in the use of psychedelic medicines for those struggling with substance use disorders. He emphasizes that there has been a significant amount of research about the use of Ketamine and other medications over the course of decades, and it's important to know how to put such research in an appropriate context. In this podcast, Michael talks about his own interest in the recovery ecosystem and the journey he has embarked on in the pursuit of helping others. He also relates his extensive background in cognitive behavioral therapy to his current Ketamine-assisted therapy practice. Additional information:
Is anyone else super hungry after their ketamine infusion? I get nausea (which I know is very common) but I also start craving comfort food right around the end of the session too.
#RefractoryOCD #KetamineAssistedTherapy #KetamineInfusion #Spoonie
Expanded Salience Network Emerges as a Promising Early Biomarker for Depression Risk — SCIENMAG
In a groundbreaking advance set to reshape the landscape of mental health diagnostics, a newly published commentary in Genomic Psychiatry highlights the identification of a neural biomarker that could revolutionize how depression is understood and treated.
Effects of ketamine on individual symptoms and symptom networks of depression in a randomised controlled trial of ketamine for treatment-resistant depression (Hossein, et al, 2025)
https://pubmed.ncbi.nlm.nih.gov/40355133/ #ketamine #depression #ketaminetherapy #ketamineassistedtherapy #mentalhealth #psychedelic #psychedelics
Effects of ketamine on individual symptoms and symptom networks of depression in a randomised controlled trial of ketamine for treatment-resistant depression - PubMed
Ketamine improved all symptoms but showed the greatest effect on symptoms of sadness, both immediately and in the initial week after treatment. Ketamine also rapidly altered the topology of symptom networks, strengthening interrelationships between residual symptoms. The efficacy of ketamine (compar …
Breaking through anhedonia: How ketamine reignites the drive for rewards - PubMed
In this issue of Neuron, Pignatelli et al.<sup>1</sup> find that ketamine reverses stress-induced changes in excitatory synapses in nucleus accumbens D1 dopamine receptor-expressing medium spiny neurons (D1-MSNs) and that these changes are necessary for the treatment of anhedonia-like behavior.
Psychedelic Institute
Rebecca Esther (they/she)
Instituto Psicodélico
