From a meeting report in #JournalImmunology:

"He (Jonathan Kagan) showed that old mice lose their naive CD8+ T cell repertoire, and the absence of CD8+ T cells in young mice reduces their survival rate. Protective immunity against cancer rises from CD4+ T cells in old mice, whereas CD8+ T cells are responsible for antitumor immunity in young mice."

#Immunotherapy #Immunology #TumorImmunology

https://journals.aai.org/jimmunol/article/209/12/2251/237566/Shedding-Light-on-Immunological-Research-in-Lyon

"In memory T cells, the frequency of CXCR5+CXCR3+CCR6− circulating follicular Th1 was positively correlated with RBD-specific Ab-secreting B cells. For the response to variant RBDs, although 60–80% of memory B cells could bind to the omicron RBD, their avidity was low, whereas memory T cells show an equal response to the omicron spike."

#Immunology #Covid #COVID19
#JournalImmunology

https://journals.aai.org/jimmunol/article/209/11/2104/237343/Memory-B-Cells-and-Memory-T-Cells-Induced-by-SARS

"The human MPYS gene is highly heterogeneous (9, 10). Approximately 50% of Americans carry a non–wild-type (WT) (R232) MPYS allele (9). R71H-G230A-R293Q (HAQ) is the second most common human MPYS allele carried by ∼25% of Americans and ∼63% of East Asians (EAS) (9). Surprisingly, we recently found that HAQ knock-in mice do not respond to CDNs in vivo (11). In corroboration, Mogensen and colleagues (12) reported that homozygous HAQ MPYS/STING was enriched in HIV-infected individuals that were long-term nonprogressors."

#Immunology #Immunogenetics #JournalImmunology

https://journals.aai.org/jimmunol/article/209/11/2114/237342/MPYS-Modulates-Fatty-Acid-Metabolism-and-Immune